During the last decade evidence from numerous studies has been accumulated
demonstrating that posttranscriptional gene regulation including mRNA turnover and …

Memory, attention and creativity represent three different cognitive domains, which are
interconnected and contribute the “mental performance” of an individual. Modern …

Localized mRNA translation regulates synapse function and axon maintenance, but how
compartment-specific mRNA repertoires are regulated is largely unknown. We developed an …

The genetic basis of myotonic dystrophy type 1 (DM1) is a CTG expansion in the 3′
untranslated region (UTR) of DMPK. The pathogenic mechanism involves an RNA gain of …

Spinal muscular atrophy (SMA) results from reduced levels of the survival of motor neuron
(SMN) protein, which has a well characterized function in spliceosomal small nuclear …

Among the pathologic hallmarks of Alzheimer's disease (AD) neurodegeneration, only
synaptic loss in the brains of AD patients closely correlates with the degree of dementia in …

GAP-43 is an intracellular growth-associated protein that appears to assist neuronal
pathfinding and branching during development and regeneration, and may contribute to …

In this study, we investigated the molecular mechanisms underlying the ATP analogue
adenosine-5′-O-(3-thio) triphosphate–induced nucleocytoplasmic shuttling of the mRNA …

In addition to transcription, posttranscriptional mechanisms play a vital role in the control of
gene expression. There are multiple levels of posttranscriptional regulation, including mRNA …

During the last decade evidence has accumulated that modulation of mRNA stability plays a
central role in cellular homeostasis, including cell differentiation, proliferation and adaptation …