Menopause is the final step in the process referred to as ovarian ageing. The age related
decrease in follicle numbers dictates the onset of cycle irregularity and the final cessation of …

The delay in childbearing is an important societal change contributing to an increasing
incidence of subfertility. The prevailing concept of female reproductive ageing assumes that …

The endocrine system dynamically controls tissue differentiation and homeostasis, but has
not been studied using dynamic tissue culture paradigms. Here we show that a microfluidic …

The menopause, defined as the permanent cessation of menstruation resulting from the loss
of ovarian follicular activity, marks the end of natural female reproductive life. It is preceded …

The increase in serum FSH that accompanies female reproductive aging occurs before
changes in estradiol (E2). A decrease in negative feedback from inhibin A (a product of the …

When it was initially discovered in 1923, inhibin was characterized as a hypophysiotropic
hormone that acts on pituitary cells to regulate pituitary hormone secretion. Ninety years …

The aim of this study was to investigate if previously oligo-or amenorrhoeic polycystic ovary
syndrome (PCOS) patients gain regular menstrual cycles when ageing. Women registered …

Follistatin is a member of the TGF-β super family and inhibits the action of myostatin to
regulate skeletal muscle growth. The regulation of follistatin during physical exercise is …

It has been 70 years since the name inhibin was used to describe a gonadal factor that
negatively regulated pituitary hormone secretion. The majority of this period was required to …

The dynamics of reproductive hormones that characterize the menopausal transition
(perimenopause) are incompletely understood, particularly in non-Caucasian women. The …