Systemic sclerosis (SSc) is a complex disease characterized by early microvascular
abnormalities, immune dysregulation and chronic inflammation, and subsequent fibrosis of …

From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …

Activation of fibroblasts is essential for physiological tissue repair. Uncontrolled activation of
fibroblasts, however, may lead to tissue fibrosis with organ dysfunction. Although several …

Background/Objective: Skin fibrosis is the result of aberrant processes leading to abnormal
deposition of extracellular matrix (ECM) in the dermis. In healthy skin, keratinocytes …

Systemic sclerosis (SSc) is a multisystem autoimmune and vascular disease resulting in
fibrosis of various organs with unknown etiology. Accumulating evidence suggests that a …

Systemic sclerosis (SS c) is a multisystem autoimmune disease characterized by
vasculopathy and tissue fibrosis of the skin and various internal organs. A series of genetic …

Systemic sclerosis (SSc, scleroderma) is a complex multisystem disease characterized by
autoimmunity, vasculopathy, and most notably, fibrosis. Multiple lines of evidence …

As the outermost layer of the skin, the epidermis is playing a major role in organism
homeostasis providing the first barrier against external aggressions. Although considered as …

Systemic sclerosis (SSc) is a rare connective tissue disease characterized by vascular
remodeling, fibroblast activation and extra-cellular matrix production in excess and …

Systemic sclerosis is a rare acquired systemic disease characterised by a complex
pathogenesis and multi organ involvement. Every year the scientific world contributes to …