The biological and clinical significance of emerging SARS-CoV-2 variants

K Tao, PL Tzou, J Nouhin, RK Gupta… - Nature Reviews …, 2021 - nature.com
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …

Is the SARS CoV-2 omicron variant deadlier and more transmissible than delta variant?

BV Duong, P Larpruenrudee, T Fang… - International journal of …, 2022 - mdpi.com
Genetic variants of severe acute respiratory syndrome coronavirus (SARS-CoV-2) have
been globally surging and devastating many countries around the world. There are at least …

Context-specific emergence and growth of the SARS-CoV-2 Delta variant

JT McCrone, V Hill, S Bajaj, RE Pena, BC Lambert… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Delta (Pango lineage B. 1.617. 2) variant of concern spread
globally, causing resurgences of COVID-19 worldwide,. The emergence of the Delta variant …

Efficacy, safety, and immunogenicity of the DNA SARS-CoV-2 vaccine (ZyCoV-D): the interim efficacy results of a phase 3, randomised, double-blind, placebo …

A Khobragade, S Bhate, V Ramaiah, S Deshpande… - The Lancet, 2022 - thelancet.com
Summary Background ZyCoV-D, a DNA-based vaccine, showed promising safety and
immunogenicity in a phase 1/2 trial. We now report the interim efficacy results of phase 3 …

Clinical characterization and genomic analysis of samples from COVID-19 breakthrough infections during the second wave among the various states of India

N Gupta, H Kaur, PD Yadav, L Mukhopadhyay… - Viruses, 2021 - mdpi.com
From March to June 2021, India experienced a deadly second wave of COVID-19, with an
increased number of post-vaccination breakthrough infections reported across the country …

[HTML][HTML] Delta variant: the new challenge of COVID-19 pandemic, an overview of epidemiological, clinical, and immune characteristics

R Rashedi, N Samieefar, M Akhlaghdoust… - Acta Bio Medica …, 2022 - ncbi.nlm.nih.gov
The SARS-CoV-2 genome has undergone several mutations since the beginning of the
pandemic in December 2019. A number of these mutants were associated with higher …

[HTML][HTML] A systematic review of vaccine breakthrough infections by SARS-CoV-2 delta variant

M Zhang, Y Liang, D Yu, B Du, W Cheng… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Vaccines are proving to be highly effective in controlling hospitalization and deaths
associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

Predicting mutational effects on receptor binding of the spike protein of SARS-CoV-2 variants

C Bai, J Wang, G Chen, H Zhang, K An… - Journal of the …, 2021 - ACS Publications
The pandemic caused by SARS-CoV-2 has cost millions of lives and tremendous
social/financial loss. The virus continues to evolve and mutate. In particular, the recently …

Biological properties of SARS-CoV-2 variants: epidemiological impact and clinical consequences

R Hoteit, HM Yassine - Vaccines, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to
the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May …

Understanding mutations in human SARS-CoV-2 spike glycoprotein: a systematic review & meta-analysis

R Kumar, Y Srivastava, P Muthuramalingam, SK Singh… - Viruses, 2023 - mdpi.com
Genetic variant (s) of concern (VoC) of SARS-CoV-2 have been emerging worldwide due to
mutations in the gene encoding spike glycoprotein. We performed comprehensive analyses …