Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …

Midcingulate cortex (MCC) has risen in prominence as human imaging identifies unique
structural and functional activity therein and this is the first review of its structure …

Objective The clinical management of inflammatory pain requires an optimal balance
between effective analgesia and associated safety risks. To date, mechanisms associated …

The monoaminergic system can be manipulated to great effect in the clinic resulting in
improved treatment outcomes and is the basis for the actions of the antidepressant drugs in …

Monoamines are involved in regulating the endogenous pain system and indeed, peripheral
and central monoaminergic dysfunction has been demonstrated in certain types of pain …

Migraine is prevalent in children and adolescents and constitutes an important cause of
disability in this population. Early, effective treatment of paediatric migraine is likely to result …

Study objective Multimodal analgesic strategies are recommended to decrease opioid
requirements and opioid-induced respiratory complications in patients undergoing …

Abstract The method of Arterial Spin Labeling (ASL) has experienced a significant rise in its
application to functional imaging, since it is the only technique capable of measuring blood …

Intravenous (IV) nonsteroidal anti-inflammatory drugs such as IV ibuprofen are increasingly
used as a component of multimodal pain management in the inpatient and outpatient …

Top–down processing pathways modulate neuronal transmission at the level of the spinal
cord dorsal horn and thus govern, in part, the percept of pain. In health, these descending …