Cross-electrophile coupling (XEC), defined by us as the cross-coupling of two different σ-
electrophiles that is driven by catalyst reduction, has seen rapid progression in recent years …

Life is constructed primarily using a toolbox of 20 canonical amino acids─ relying upon
these building blocks for the assembly of proteins and peptides that regulate nearly every …

Zinc and manganese are widely used as reductants in synthetic methods, such as nickel-
catalysed cross-electrophile coupling (XEC) reactions, but their redox potentials are …

An electrochemical, nickel-catalyzed reductive coupling of alkylpyridinium salts and aryl
halides is reported. High-throughput experimentation (HTE) was employed for rapid reaction …

The exploration of strong chemical bonds as synthetic handles offers new disconnection
strategies for the synthesis of functionalized molecules via transition metal catalysis …

Amines and carboxylic acids are abundant synthetic building blocks that are classically
united to form an amide bond. To access new pockets of chemical space, we are interested …

In contemporary drug discovery, enhancing the sp3-hybridized character of molecular
structures is paramount, necessitating innovative synthetic methods. Herein, we introduce a …

Herein, we present the example of Cu-catalyzed oxidation coupling of amino acids/peptides
for producing α-alkylated unnatural glycine derivatives by the activation of double C (sp3) …

While being among the most common functional handles present in organic molecules,
amines are a widely underutilized linchpin for C–C bond formation. To facilitate C–N bond …

The Stille cross‐coupling reaction is one of the most common strategies for the construction
of C− C bonds. Despite notable strides in the advancement of the Stille reaction, persistent …