Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

It is now well accepted that diabetes mellitus is one of the main threats to human health in
the twenty-first century. The total number of people with diabetes worldwide was estimated …

INTRODUCTION Despite the father transmitting half of the heritable information to the
embryo, the focus of preconception health has been the mother. Paternal effects have been …

Oncogenic Kras activates a plethora of signaling pathways, but our understanding of critical
Ras effectors is still very limited. We show that cell-autonomous phosphoinositide 3-kinase …

Diabetes is the most common metabolic disorder, with an extremely serious effect on health
systems worldwide. It has become a severe, chronic, non-communicable disease after …

The prevalence of type‐2 diabetes (T2D) is increasing significantly throughout the globe
since the last decade. This heterogeneous and multifactorial disease, also known as insulin …

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of metabolic
and nutrient cues that integrates environmental inputs into downstream signaling pathways …

To maintain the female reproductive lifespan, the majority of ovarian primordial follicles are
preserved in a quiescent state in order to provide ova for later reproductive life. However, the …

OBJECTIVE—MicroRNAs are short, noncoding RNAs that regulate gene expression. We
hypothesized that the phosphatidylinositol 3-kinase (PI 3-kinase) cascade known to be …

Insulin is a life-saving drug for patients with type 1 diabetes; however, even today, no
pharmacotherapy can prevent the loss or dysfunction of pancreatic insulin-producing β cells …