Structural characterization of the O-GlcNAc cycling enzymes: insights into substrate recognition and catalytic mechanisms
Highlights•O-GlcNAc modification of nuclear and cytoplasmic proteins is critical in metazoan
biology.•The enzymes OGT and OGA attach and remove O-GlcNAc, respectively.•OGT also …
biology.•The enzymes OGT and OGA attach and remove O-GlcNAc, respectively.•OGT also …
[HTML][HTML] A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation
P Latorre-Muro, KE O'Malley, CF Bennett, EA Perry… - Cell metabolism, 2021 - cell.com
The architecture of cristae provides a spatial mitochondrial organization that contains
functional respiratory complexes. Several protein components including OPA1 and MICOS …
functional respiratory complexes. Several protein components including OPA1 and MICOS …
Structure-based evolution of low nanomolar O-GlcNAc transferase inhibitors
SES Martin, ZW Tan, HM Itkonen… - Journal of the …, 2018 - ACS Publications
Reversible glycosylation of nuclear and cytoplasmic proteins is an important regulatory
mechanism across metazoans. One enzyme, O-linked N-acetylglucosamine transferase …
mechanism across metazoans. One enzyme, O-linked N-acetylglucosamine transferase …
Mammalian cell proliferation requires noncatalytic functions of O-GlcNAc transferase
O-GlcNAc transferase (OGT), found in the nucleus and cytoplasm of all mammalian cell
types, is essential for cell proliferation. Why OGT is required for cell growth is not known …
types, is essential for cell proliferation. Why OGT is required for cell growth is not known …
Identification and characterization of a missense mutation in the O-linked β-N-acetylglucosamine (O-GlcNAc) transferase gene that segregates with X-linked …
K Vaidyanathan, T Niranjan, N Selvan, CF Teo… - Journal of Biological …, 2017 - ASBMB
O-GlcNAc is a regulatory post-translational modification of nucleocytoplasmic proteins that
has been implicated in multiple biological processes, including transcription. In humans …
has been implicated in multiple biological processes, including transcription. In humans …
Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability
AP Willems, M Gundogdu, MJE Kempers… - Journal of Biological …, 2017 - ASBMB
N-Acetylglucosamine (O-GlcNAc) transferase (OGT) regulates protein O-GlcNAcylation, an
essential and dynamic post-translational modification. The O-GlcNAc modification is present …
essential and dynamic post-translational modification. The O-GlcNAc modification is present …
Sequence-selective decapeptide synthesis by the parallel operation of two artificial molecular machines
J Echavarren, MAY Gall, A Haertsch… - Journal of the …, 2021 - ACS Publications
We report on the preparation of a decapeptide through the parallel operation of two rotaxane-
based molecular machines. The synthesis proceeds in four stages:(1) simultaneous …
based molecular machines. The synthesis proceeds in four stages:(1) simultaneous …
Identification of a Polypeptide Inhibitor of O-GlcNAc Transferase with Picomolar Affinity
FA Hammel, NC Payne, VM Marando… - Journal of the …, 2024 - ACS Publications
O-GlcNAc transferase (OGT) is an essential mammalian enzyme that binds thousands of
different proteins, including substrates that it glycosylates and nonsubstrate interactors that …
different proteins, including substrates that it glycosylates and nonsubstrate interactors that …
Discovery of a low toxicity O-GlcNAc transferase (OGT) inhibitor by structure-based virtual screening of natural products
O-GlcNAc transferase (OGT) plays an important role in regulating numerous cellular
processes through reversible post-translational modification of nuclear and cytoplasmic …
processes through reversible post-translational modification of nuclear and cytoplasmic …