The sodium/potassium-ATPase (NKA) is the enzyme that establishes gradients of sodium
and potassium across the plasma membrane. NKA activity is tightly regulated for different …

Background Blood glucose levels are tightly controlled by the coordinated actions of
hormone-producing endocrine cells that reside in pancreatic islets. Islet cell malfunction …

In transplantation, there is a critical need for noninvasive biomarker platforms for monitoring
immunologic rejection. We hypothesized that transplanted tissues release donor-specific …

Extracellular vesicles (EVs) are naturally released, cell-derived vesicles that mediate
intracellular communication, in part, by transferring genetic information and, thus, have the …

There are presently no reliable ways to quantify endocrine cell mass (ECM) in vivo, which
prevents an accurate understanding of the progressive beta cell loss in diabetes or following …

For more than a decade, researchers have been trying to develop non-invasive imaging
techniques for the in vivo measurement of viable pancreatic beta cells. However, in spite of …

Pancreatic β‐cell dysfunction and death are determinant events in type 1 diabetes (T1D), but
the molecular mechanisms behind β‐cell fate remain poorly understood. Alternative splicing …

Background and Methodology The aim of this study was to establish a gene expression
blueprint of pancreatic beta cells conserved from rodents to humans and to evaluate its …

Aims/hypothesis The aim of the study was to identify surface bio-markers and corresponding
antibody tools that can be used for the imaging and immunoisolation of the pancreatic beta …

Abstract Type 1 diabetes (T1D) is a devastating disease precipitated by an autoimmune
response directed at the insulin-producing beta-cells of the pancreas for which no cure …