Structural perspectives on chemokine receptors
K Kayastha, Y Zhou, S Brünle - Biochemical Society …, 2024 - portlandpress.com
Chemokine receptors are integral to the immune system and prime targets in drug discovery
that have undergone extensive structural elucidation in recent years. We outline a timeline of …
that have undergone extensive structural elucidation in recent years. We outline a timeline of …
Optimization of triazolo [4, 5-d] pyrimidines towards human CC chemokine receptor 7 (CCR7) antagonists
M Van Hoof, S Claes, M Proj, T Van Loy… - European journal of …, 2023 - Elsevier
CCR7 signaling directs the migration of both immune cells and cancer cells to the lymph
nodes, is involved in numerous chronic inflammatory disorders and lymph node metastases …
nodes, is involved in numerous chronic inflammatory disorders and lymph node metastases …
Second generation Al18F-labeled D-amino acid peptide for CXCR4 targeted molecular imaging
MA Spahn, K Luyten, T Van Loy, M Sathekge… - Nuclear Medicine and …, 2024 - Elsevier
Background The CXC chemokine receptor type 4 (CXCR4) is overexpressed in many
cancers, eg multiple myeloma and acute leukemia, yet solely [68 Ga] PentixaFor is used for …
cancers, eg multiple myeloma and acute leukemia, yet solely [68 Ga] PentixaFor is used for …
Synthesis of CXCR2 and CCR7 chemokine receptor antagonists targeting a conserved intracellular binding site
M Van Hoof, W Dehaen, S De Jonghe - 2023 - lirias.kuleuven.be
Chemokines are a class of small, secreted proteins (8-12 kDa) that direct cellular trafficking
and leukocyte migration to sites of inflammation and tumor growth. They are classified into …
and leukocyte migration to sites of inflammation and tumor growth. They are classified into …