A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Integrins as biomechanical sensors of the microenvironment

JZ Kechagia, J Ivaska, P Roca-Cusachs - Nature reviews Molecular cell …, 2019 - nature.com
Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …

Fibronectin: molecular structure, fibrillar structure and mechanochemical signaling

CJ Dalton, CA Lemmon - Cells, 2021 - mdpi.com
The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of
cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate …

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

B Erdogan, M Ao, LM White, AL Means… - Journal of Cell …, 2017 - rupress.org
Cancer-associated fibroblasts (CAFs) are major components of the carcinoma
microenvironment that promote tumor progression. However, the mechanisms by which …

4D printing: a review on recent progresses

H Chu, W Yang, L Sun, S Cai, R Yang, W Liang, H Yu… - Micromachines, 2020 - mdpi.com
Since the late 1980s, additive manufacturing (AM), commonly known as three-dimensional
(3D) printing, has been gradually popularized. However, the microstructures fabricated …

The oyster genome reveals stress adaptation and complexity of shell formation

G Zhang, X Fang, X Guo, LI Li, R Luo, F Xu, P Yang… - Nature, 2012 - nature.com
Abstract The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but
genomically poorly explored phyla, the Mollusca. Here we report the sequencing and …

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System for In Vitro Investigation

AJ Booth, R Hadley, AM Cornett, AA Dreffs… - American journal of …, 2012 - atsjournals.org
Rationale: Extracellular matrix (ECM) is a dynamic tissue that contributes to organ integrity
and function, and its regulation of cell phenotype is a major aspect of cell biology. However …

Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers

KL Ellefsen, JR Holt, AC Chang, JL Nourse… - Communications …, 2019 - nature.com
Piezo channels transduce mechanical stimuli into electrical and chemical signals to
powerfully influence development, tissue homeostasis, and regeneration. Studies on Piezo1 …

Plasma and cellular fibronectin: distinct and independent functions during tissue repair

WS To, KS Midwood - Fibrogenesis & tissue repair, 2011 - Springer
Fibronectin (FN) is a ubiquitous extracellular matrix (ECM) glycoprotein that plays vital roles
during tissue repair. The plasma form of FN circulates in the blood, and upon tissue injury, is …

Integrins and extracellular matrix in mechanotransduction

MA Schwartz - Cold Spring Harbor perspectives in …, 2010 - cshperspectives.cshlp.org
Integrins bind extracellular matrix fibrils and associate with intracellular actin filaments
through a variety of cytoskeletal linker proteins to mechanically connect intracellular and …