Sea anemones produce venoms of exceptional molecular diversity, with at least 17 different
molecular scaffolds reported to date. These venom components have traditionally been …

Pore-forming proteins (PFPs) are a heterogeneous group of proteins that are expressed and
secreted by a wide range of organisms. PFPs are produced as soluble monomers that bind …

Pore-forming protein toxins (PFTs) represent a diverse class of membrane-damaging
proteins that are produced by a wide variety of organisms. PFT-mediated membrane …

Highlights•PFPs are fundamental defense and virulence factors in bacteria and as executors
of regulated cell death in eukaryotic cells.•Proteins and lipids cooperate to form different …

Sticholysins are pore-forming toxins of biomedical interest and represent a prototype of
proteins acting through the formation of protein-lipid or toroidal pores. Peptides spanning the …

Actinoporins (APs) are soluble pore-forming proteins secreted by sea anemones that
experience conformational changes originating in pores in the membranes that can lead to …

Sticholysin II (StII) is a pore-forming toxin of biomedical interest that belongs to the
actinoporin protein family. Sticholysins are currently under examination as an active …

Non-viral gene delivery systems offer significant potential for gene therapy due to their
versatility, safety, and cost advantages over viral vectors. However, their effectiveness can …

Background: Pore-forming proteins (PFP) are a class of toxins abundant in the venom of sea
anemones. Owing to their ability to recognize and permeabilize cell membranes, pore …

Animal venoms are a complex mixture of highly specialized toxic molecules. Among them,
pore-forming proteins (PFPs) or toxins (PFTs) are one of the major disease-causing toxic …