Fibromyalgia (FM) is characterized by chronic widespread musculoskeletal pain associated
with sleep problems, fatigue, depression, and anxiety. The persistence of pain, impairment …

Clinical sequelae and symptoms for a considerable number of COVID-19 patients can linger
for months beyond the acute stage of SARS-CoV-2 infection,“long COVID”. Among the long …

It is widely accepted that the pathophysiology and treatment of myalgic encephalomyelitis/
chronic fatigue syndrome (ME/CFS) could be considerably improved. The heterogeneity of …

The concept of fibromyalgia has progressed to achieve a certain consensus regarding the
definition of the condition. We summarize what is known in 2020, be it in terms of diagnosis …

Cardiovascular diseases (CVDs) are the leading global cause of mortality and disability,
tending to happen in younger individuals in developed countries. Despite improvements in …

Gastrointestinal (GI) cancers, leading causes of cancer-related deaths, have been serious
challenging human diseases up to now. Because of high rates of mortality, late-stage …

Chronic pain has been proven to be an independent disease, other than an accompanying
symptom of certain diseases. Interleukin-18 (IL-18), a pro-inflammatory cytokine with …

The multimorbidity formed by sleep disturbances and pain conditions is highly prevalent and
has a significant impact in global health and in the socioeconomic system. Although different …

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multisystem,
and profoundly debilitating condition, probably of multifactorial etiology. No effective …

Abstract Purpose of Review The purpose of this review is to provide a summary of the
utilization of sleep as a therapeutic target for chronic pain and to evaluate the recent …