Lysosomes are catabolic organelles that govern numerous cellular processes, including
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …

The etiology of idiopathic Parkinson's disease (iPD) is multifactorial, and both genetics and
environmental exposures are risk factors. While mutations in leucine-rich repeat kinase-2 …

Age‐related diseases represent some of the largest unmet clinical needs of our time. While
treatment of specific disease‐related signs has had some success (for example, the effect of …

The Rag GTPases are an evolutionarily conserved family that play a crucial role in amino
acid sensing by the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 is often …

Abstract The Lys-Asp-Glu-Leu receptor (KDELR) family genes play critical roles in a variety
of biological processes in different tumors. Our study aimed to provide a comprehensive …

Mammalian target of rapamycin complex 1 (mTORC1) senses amino acids to control cell
growth, metabolism, and autophagy. Some amino acids signal to mTORC1 through the Rag …

The Arf family proteins are best known for their roles in the vesicle biogenesis. However,
they also play fundamental roles in a wide range of cellular regulation besides vesicular …

Spatial proteomics aims for a global description of organelle-specific protein distribution and
dynamics, which is essential for understanding the molecular functions and cellular …

Background mTORC2 is a critical regulator of cytoskeleton organization, cell proliferation,
and cancer cell survival. Activated mTORC2 induces maximal activation of Akt by …

Pancreatic islets comprise a group of cells that produce hormones regulating blood glucose
levels. Particularly, the alpha and beta islet cells produce glucagon and insulin to stabilize …