Unsupervised machine learning for exploratory data analysis in imaging mass spectrometry

N Verbeeck, RM Caprioli… - Mass spectrometry …, 2020 - Wiley Online Library
Imaging mass spectrometry (IMS) is a rapidly advancing molecular imaging modality that
can map the spatial distribution of molecules with high chemical specificity. IMS does not …

Age-related macular degeneration

M Fleckenstein, TDL Keenan, RH Guymer… - Nature reviews Disease …, 2021 - nature.com
Age-related macular degeneration (AMD) is the leading cause of legal blindness in the
industrialized world. AMD is characterized by accumulation of extracellular deposits, namely …

Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation

M Hata, EMMA Andriessen, M Hata, R Diaz-Marin… - Science, 2023 - science.org
Age-related macular degeneration is a prevalent neuroinflammatory condition and a major
cause of blindness driven by genetic and environmental factors such as obesity. In diseases …

[HTML][HTML] Soft drusen in age-related macular degeneration: biology and targeting via the oil spill strategies

CA Curcio - Investigative ophthalmology & visual science, 2018 - iovs.arvojournals.org
AMD is a major cause of legal blindness in older adults approachable through
multidisciplinary research involving human tissues and patients. AMD is a vascular …

[HTML][HTML] A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration

JT Handa, C Bowes Rickman, AD Dick… - Nature …, 2019 - nature.com
Age-related macular degeneration (AMD) is the most common cause of blindness among
the elderly in the developed world. While treatment is effective for the neovascular or “wet” …

Subretinal drusenoid deposits AKA pseudodrusen

RF Spaide, S Ooto, CA Curcio - Survey of ophthalmology, 2018 - Elsevier
A distinction between conventional drusen and pseudodrusen was first made in 1990, and
more recently knowledge of pseudodrusen, more accurately called subretinal drusenoid …

[HTML][HTML] A new perspective on lipid research in age-related macular degeneration

EM van Leeuwen, E Emri, BMJ Merle, JM Colijn… - Progress in retinal and …, 2018 - Elsevier
There is an urgency to find new treatment strategies that could prevent or delay the onset or
progression of AMD. Different classes of lipids and lipoproteins metabolism genes have …

Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological …

KN Khan, OA Mahroo, RS Khan, MD Mohamed… - Progress in retinal and …, 2016 - Elsevier
Drusen are discussed frequently in the context of their association with age-related macular
degeneration (AMD). Some types may, however, be regarded as a normal consequence of …

Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration

ACS Tan, MG Pilgrim, S Fearn, S Bertazzo… - Science translational …, 2018 - science.org
Drusen are lipid-, mineral-, and protein-containing extracellular deposits that accumulate
between the basal lamina of the retinal pigment epithelium (RPE) and Bruch's membrane …

[HTML][HTML] The clinical relevance of visualising the peripheral retina

N Quinn, L Csincsik, E Flynn, CA Curcio, S Kiss… - Progress in retinal and …, 2019 - Elsevier
Recent developments in imaging technologies now allow the documentation, qualitative and
quantitative evaluation of peripheral retinal lesions. As wide field retinal imaging, capturing …