Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity
MC Smith, JE Gestwicki - Expert reviews in molecular medicine, 2012 - cambridge.org
Protein–protein interactions (PPIs) control the assembly of multi-protein complexes and,
thus, these contacts have enormous potential as drug targets. However, the field has …
thus, these contacts have enormous potential as drug targets. However, the field has …
Organization of the ENaC-regulatory machinery
R Soundararajan, M Lu, D Pearce - Critical reviews in biochemistry …, 2012 - Taylor & Francis
The control of fluid and electrolyte homeostasis in vertebrates requires the integration of a
diverse set of signaling inputs, which control epithelial Na+ transport, the principal ionic …
diverse set of signaling inputs, which control epithelial Na+ transport, the principal ionic …
Inhibitors of difficult protein–protein interactions identified by high-throughput screening of multiprotein complexes
Protein–protein interactions (PPIs) are important in all aspects of cellular function, and there
is interest in finding inhibitors of these contacts. However, PPIs with weak affinities and/or …
is interest in finding inhibitors of these contacts. However, PPIs with weak affinities and/or …
Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers
Transcription factors control the fate of a cell by regulating the expression of genes and
regulatory networks. Recent successes in inducing pluripotency in terminally differentiated …
regulatory networks. Recent successes in inducing pluripotency in terminally differentiated …
Citric acid cycle and the origin of MARS
SM Eswarappa, PL Fox - Trends in biochemical sciences, 2013 - cell.com
The vertebrate multiaminoacyl tRNA synthetase complex (MARS) is an assemblage of nine
aminoacyl tRNA synthetases (ARSs) and three non-synthetase scaffold proteins, aminoacyl …
aminoacyl tRNA synthetases (ARSs) and three non-synthetase scaffold proteins, aminoacyl …
Integrative systems and synthetic biology of cell-matrix adhesion sites
E Zamir - Cell Adhesion & Migration, 2016 - Taylor & Francis
The complexity of cell-matrix adhesion convolves its roles in the development and
functioning of multicellular organisms and their evolutionary tinkering. Cell-matrix adhesion …
functioning of multicellular organisms and their evolutionary tinkering. Cell-matrix adhesion …
Distinct regulatory pathways controlling NLRP3 inflammasome in infectious and non-infectious diseases
M Ghait - 2022 - db-thueringen.de
The proper response of immune cells to pathogenic cues is tightly regulated by elaborate
mechanisms to control their onset, intensity and termination. Inflammasomes are large …
mechanisms to control their onset, intensity and termination. Inflammasomes are large …
Strategies and Functional Consequences of Inhibiting Protein-Protein Interactions.
L Cesa - 2016 - deepblue.lib.umich.edu
Networks of protein-protein interactions (PPIs) are essential in all aspects of cellular biology.
At the nodes of these networks are multi-protein complexes that are often composed of …
At the nodes of these networks are multi-protein complexes that are often composed of …