Systemic lupus erythematosus (SLE) is recognized as a prevalent autoimmune disorder
characterized by a multifaceted pathogenesis potentially influenced by a combination of …

Inflammasomes are intracellular multiprotein complexes that activate inflammatory signaling
pathways. Inflammasomes comprise two major classes: canonical inflammasomes, which …

Defining the molecular mechanisms underlying cardiac resilience is crucial to find effective
approaches to protect the heart. A physiologic level of ROS is produced in the heart by fatty …

Rationale: The introduction of combination therapy utilizing tyrosine kinase inhibitors (TKIs)
and immune checkpoint inhibitors for advanced hepatocellular carcinoma (HCC) has …

The absence of stimulator of interferon genes (STING) in 129. B6. Fcgr2b-deficient mice
rescue lupus phenotypes. The administration of a STING inhibitor (ISD017) into the young …

The complexity of systemic lupus erythematosus (SLE) arises from intricate genetic and
environmental interactions, with STING playing a pivotal role. This study aims to …

RESULTS Our results showed that PPW extract-treated activated cells significantly decrease
reactive oxygen species and nitric oxide levels by reducing the p22 phox and iNOS …

Mycobacterium tuberculosis (M. tb) is a significant intracellular pathogen responsible for
numerous infectious disease‐related deaths worldwide. It uses ESX‐1 T7SS to damage …

Aging-associated inflammation, or 'inflammaging” is a driver of multiple age-associated
diseases. Cyclic GMP-AMP Synthase (cGAS) is a cytosolic DNA sensor that functions to …

The Cre-driven tdTomato reporter system is widely used to visualize gene expression and
cellular dynamics. Here we tested the impact of the tdTomato reporter system on the …