Oxidative stress and DNA damage in the mechanism of fetal alcohol spectrum disorders

S Bhatia, DM Drake, L Miller, PG Wells - Birth defects research, 2019 - Wiley Online Library
This review covers molecular mechanisms involving oxidative stress and DNA damage that
may contribute to morphological and functional developmental disorders in animal models …

Effect of alcohol on hippocampal-dependent plasticity and behavior: role of glutamatergic synaptic transmission

RG Mira, M Lira, C Tapia-Rojas… - Frontiers in behavioral …, 2020 - frontiersin.org
Problematic alcohol drinking and alcohol dependence are an increasing health problem
worldwide. Alcohol abuse is responsible for approximately 5% of the total deaths in the …

Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming

L Liu, Y Wen, Q Ni, L Chen, H Wang - Biological Research, 2023 - Springer
Prenatal ethanol exposure (PEE)(mainly through maternal alcohol consumption) has
become widespread. However, studies suggest that it can cause intrauterine growth …

Insights into retinoic acid deficiency and the induction of craniofacial malformations and microcephaly in fetal alcohol spectrum disorder

B Petrelli, L Bendelac, GG Hicks, A Fainsod - Genesis, 2019 - Wiley Online Library
Summary Fetal Alcohol Spectrum Disorder (FASD) is a set of neurodevelopmental
malformations caused by maternal consumption of alcohol during pregnancy. FASD sentinel …

Combined face–brain morphology and associated neurocognitive correlates in fetal alcohol spectrum disorders

M Suttie, JR Wozniak, SE Parnell… - Alcoholism: Clinical …, 2018 - Wiley Online Library
Background Since the 1970s, a range of facial, neurostructural, and neurocognitive adverse
effects have been shown to be associated with prenatal alcohol exposure. Typically, these …

Translational structural and functional signatures of chronic alcohol effects in mice

L Degiorgis, TM Arefin, S Ben-Hamida, V Noblet… - Biological …, 2022 - Elsevier
Background Alcohol acts as an addictive substance that may lead to alcohol use disorder. In
humans, magnetic resonance imaging showed diverse structural and functional brain …

Prenatal alcohol exposure disrupts Sonic hedgehog pathway and primary cilia genes in the mouse neural tube

KE Boschen, EW Fish, SE Parnell - Reproductive Toxicology, 2021 - Elsevier
Neurulation-stage alcohol exposure (NAE; embryonic day [E] 8–10) is associated with
midline craniofacial and CNS defects that likely arise from disruption of morphogen …

Ethanol and cannabinoids interact to alter behavior in a zebrafish fetal alcohol spectrum disorder model

O Boa‐Amponsem, C Zhang… - Birth defects …, 2019 - Wiley Online Library
Background Recent work suggests that endocannabinoids (eCBs) may signal through the
sonic hedgehog signaling pathway. We therefore hypothesized that combined ethanol and …

[HTML][HTML] Ketamine administered pregnant rats impair learning and memory in offspring via the CREB pathway

X Li, C Guo, Y Li, L Li, Y Wang, Y Zhang, Y Li, Y Chen… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Ketamine has been reported to impair the capacity for learning and memory. This study
examined whether these capacities were also altered in the offspring and investigated the …

Neonatal alcohol exposure reduces number of parvalbumin-positive interneurons in the medial prefrontal cortex and impairs passive avoidance acquisition in mice …

GF Hamilton, IJ Hernandez, CP Krebs, PJ Bucko… - Neuroscience, 2017 - Elsevier
Developmental alcohol exposure causes a host of cognitive and neuroanatomical
abnormalities, one of which is impaired executive functioning resulting from medial …