N− C Biaryl atropisomers are prevalent in natural products and bioactive drug molecules.
However, the enantioselective synthesis of such molecules has not developed significantly …

It has been hypothesised that drugs in the chemical space “beyond the rule of 5”(bRo5) must
behave as molecular chameleons to combine otherwise conflicting properties, including …

Halogen bonding is a weak chemical force that has so far mostly found applications in
crystal engineering. Despite its potential for use in drug discovery, as a new molecular tool …

The ability to adjust conformations in response to the polarity of the environment, ie
molecular chameleonicity, is considered to be important for conferring both high aqueous …

New Syntheses and Properties of Some Axial and Helical Isomers of Organic Compounds |
Russian Journal of Organic Chemistry Skip to main content SpringerLink Account Menu Find …

Dynamic chirality influences numerous processes in nature from protein folding to catalysis.
Azapeptides are peptidomimetics possessing semicarbazide residues that can interconvert …

Structure-based drug discovery (SBDD) is a cornerstone of modern medicinal chemistry and
has inspired countless small molecule lead optimization efforts and contributed to the …

Protein–protein interactions that have large, flat and featureless binding sites are difficult
drug targets. In the development of their modulators conventional drug discovery strategies …

Abstract NAMFIS (NMR Analysis of Molecular Flexibility In Solution) was applied to 1‐[2‐
(benzyloxy) phenyl] ethanone using quantitative 1H‐1H NOE distances and 3J proton …

Новые методы синтеза и свойства некоторых аксиальных и спироизомеров органических
соединений КОРЗИНА ПОИСК НАВИГАТОР СЕССИЯ КОНТАКТЫ ИНФОРМАЦИЯ О …