Molecular evolution offers an insightful theory to interpret the genomic consequences of
thermal adaptation to previous events of climate change beyond range shifts. However …

There are a plethora of antibiotic resistance cases and humans are marching towards
another big survival test of evolution along with drastic climate change and infectious …

In Japan, bezafibrate (BF) is a second‐line agent for primary biliary cholangitis (PBC) that is
refractory to ursodeoxycholic acid (UDCA) treatment. From a retrospective cohort (n= 873) …

Resistance to standard and novel therapies remains the main obstacle to cure in acute
myeloid leukaemia (AML) and is often driven by metabolic adaptations which are …

The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no
approved antifibrotic treatments available. The adult zebrafish has been an underutilized …

Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation), a dynamic post-
translational modification (PTM), holds profound implications in controlling various cellular …

Reactive oxygen species (ROS) carry out prime physiological roles as intracellular signaling
agents, yet pathologically high concentrations of ROS cause irreversible damage to …

There is a growing need for the discovery of new prognostic factors for cases where the
scoring and staging system of hepatocellular carcinoma (HCC) does not result in a clear …

In metazoans, thousands of intracellular proteins are modified with O-linked β-N-
acetylglucosamine (O-GlcNAc) in response to a wide range of stimuli and stresses. In …

Centrosome-associated proteins are recognized as prognostic factors in many cancers
because centrosomes are critical structures for the cell cycle progression and genomic …