Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Metabolism of excess methionine (Met) to homocysteine (Hcy) by transmethylation is
facilitated by the expression of methionine adenosyltransferase (MAT) I/III and glycine N …

Hydrogen sulfide (H2S) has emerged as a relevant signaling molecule in physiology, taking
its seat as a bona fide gasotransmitter akin to nitric oxide (NO) and carbon monoxide (CO) …

The heme iron complex is one of the most important cofactors in biological systems (Figure
1). The major functions of the heme iron complex are to serve as the O2 binding site for …

Significance: Cancer represents a major socioeconomic problem; there is a significant need
for novel therapeutic approaches targeting tumor-specific pathways. Recent Advances: In …

Cystathionine β‐synthase (CBS) regulates homocysteine metabolism and contributes to
hydrogen sulfide (H2S) biosynthesis through which it plays multifunctional roles in the …

Reactive sulfur species (RSS) have been recognized in the last two decades as very
important molecules in redox regulation. They are involved in metabolic processes and, in …

Metabolism is the sum of the life-giving chemical processes that occur within a cell. Proper
regulation of these processes is essential for all organisms to thrive and prosper. When …

Cystathionine beta-synthase (CBS) is a pivotal enzyme of the transsulfuration pathway
responsible for diverting homocysteine to the biosynthesis of cysteine and production of …