Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

Drug-induced liver injury (DILI) is a major concern for the pharmaceutical industry and
constitutes one of the most important reasons for the termination of promising drug …

The liver plays an important role in xenobiotic metabolism and represents a primary target
for toxic substances. Many different in vitro cell models have been developed in the past …

While whole animal studies have their place in risk assessment of food and feed
components, it is thought that more modern approaches such as human focused new …

Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In
addition, currently available in vitro methods do not allow for the estimation of hepatotoxic …

Conclusions: This study indicates that DOCK2 controls CD8+ T-cell infiltration in HCC, and
cholesterol sulfate synthesized by sulfotransferase 2B1 in tumor cells promotes effector T …

Epigenetic modifications (eg DNA methylation) in NAFLD and their contribution to disease
progression and extrahepatic complications are poorly explored. Here, we use an integrated …

Test systems to identify developmental toxicants are urgently needed. A combination of
human stem cell technology and transcriptome analysis was to provide a proof of concept …

Adaptive stress response pathways play a key role in the switch between adaptation and
adversity, and are important in drug-induced liver injury. Previously, we have established an …

Read-across approaches often remain inconclusive as they do not provide sufficient
evidence on a common mode of action across the category members. This read-across case …