Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …

Pharmacological activation of voltage-gated ion channels by ligands serves as the basis for
therapy and mainly involves a classic gating mechanism that augments the native voltage …

Calcium is a highly positively charged ionic species. It regulates all cell types' functions and
is an important second messenger that controls and triggers several mechanisms, including …

Parkinson's disease (PD) is a common neurodegenerative disorder of middle-aged and
elderly people, clinically characterized by resting tremor, myotonia, reduced movement, and …

N-methyl-D-aspartate receptors (NMDARs) play vital roles in normal brain functions (ie,
learning, memory, and neuronal development) and various neuropathological conditions …

Subunit-selective inhibition of N-methyl-d-aspartate receptors (NMDARs) is a promising
therapeutic strategy for several neurological disorders, including epilepsy, Alzheimer's and …

This review focuses on the activity-dependent diffusion trapping of α-amino-3-hydroxy-5-
methyl-4-isoxazolepropionic acid receptors (AMPARs) as a crucial mechanism for the …

Excessive Ca2+ influx through N-methyl-D-aspartate type glutamate receptors (NMDAR) is
associated with excitotoxicity and neuronal death, but the inhibition of this receptor-channel …

The electrical activity of neurons, central to brain function, is performed by many families of
ionotropic receptors and ion channels. The gold standard technique for measuring the …