Anecdotal evidence that cannabis preparations have medical benefits together with the discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …
Cannabinoid receptors, endocannabinoids and the enzymes responsible for their biosynthesis and degradation constitute the endocannabinoid system. In recent decades …
H Xicoy, B Wieringa, GJM Martens - Cells, 2019 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …
D Haspula, MA Clark - International journal of molecular sciences, 2020 - mdpi.com
The identification of the human cannabinoid receptors and their roles in health and disease, has been one of the most significant biochemical and pharmacological advancements to …
EB Russo - Cannabis and cannabinoid research, 2016 - liebertpub.com
Medicine continues to struggle in its approaches to numerous common subjective pain syndromes that lack objective signs and remain treatment resistant. Foremost among these …
Most neurodegenerative disorders (NDD s) are characterized by cognitive impairment and other neurological defects. The definite cause of and pathways underlying the progression …
Lipids in the brain are major components playing structural functions as well as physiological roles in nerve cells, such as neural communication, neurogenesis, synaptic …
M Politis - Nature Reviews Neurology, 2014 - nature.com
Over the past three decades, neuroimaging studies—including structural, functional and molecular modalities—have provided invaluable insights into the mechanisms underlying …
EB Russo - Frontiers in integrative neuroscience, 2018 - frontiersin.org
Neurological therapeutics have been hampered by its inability to advance beyond symptomatic treatment of neurodegenerative disorders into the realm of actual palliation …