Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression

E Yang, X Wang, Z Gong, M Yu, H Wu… - Signal transduction and …, 2020 - nature.com
Metabolic reprogramming is reported to be one of the hallmarks of cancer, which is an
adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy …

[HTML][HTML] Obesity, diabetes, and increased cancer progression

DS Kim, PE Scherer - Diabetes & metabolism journal, 2021 - synapse.koreamed.org
Rates of obesity and diabetes have increased significantly over the past decades and the
prevalence is expected to continue to rise further in the coming years. Many observations …

American Association of Clinical Endocrinology clinical practice guideline: developing a diabetes mellitus comprehensive care plan—2022 update

L Blonde, GE Umpierrez, SS Reddy, JB McGill… - Endocrine Practice, 2022 - Elsevier
Objective The objective of this clinical practice guideline is to provide updated and new
evidence-based recommendations for the comprehensive care of persons with diabetes …

[HTML][HTML] Pathophysiology of obesity and its associated diseases

X Jin, T Qiu, L Li, R Yu, X Chen, C Li, CG Proud… - … Pharmaceutica Sinica B, 2023 - Elsevier
The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …

Cancer as a matter of fat: the crosstalk between adipose tissue and tumors

E Lengyel, L Makowski, J DiGiovanni, MG Kolonin - Trends in cancer, 2018 - cell.com
Obesity has been linked to the increased risk and aggressiveness of many types of
carcinoma. A state of chronic inflammation in adipose tissue (AT), resulting in genotoxic …

Cell-based drug delivery systems and their in vivo fate

L Yang, Y Yang, Y Chen, Y Xu, J Peng - Advanced Drug Delivery Reviews, 2022 - Elsevier
Cell-based drug delivery systems (DDSs) have received attention recently because of their
unique biological properties and self-powered functions, such as excellent biocompatibility …

Obesity and prostate cancer—microenvironmental roles of adipose tissue

A Saha, MG Kolonin, J DiGiovanni - Nature Reviews Urology, 2023 - nature.com
Obesity is known to have important roles in driving prostate cancer aggressiveness and
increased mortality. Multiple mechanisms have been postulated for these clinical …

Obesity and gastrointestinal cancer: the interrelationship of adipose and tumour microenvironments

J O'Sullivan, J Lysaght, CL Donohoe… - Nature reviews …, 2018 - nature.com
Increasing recognition of an association between obesity and many cancer types exists, but
how the myriad of local and systemic effects of obesity affect key cellular and non-cellular …

[HTML][HTML] Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer

AK Pingili, M Chaib, LM Sipe, EJ Miller, B Teng… - Cell reports, 2021 - cell.com
Immune checkpoint blockade (ICB) has improved outcomes in some cancers. A major
limitation of ICB is that most patients fail to respond, which is partly attributable to …

Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway

S Wang, X Su, M Xu, X Xiao, X Li, H Li… - Stem cell research & …, 2019 - Springer
Objective Although adipocytes are the most abundant stromal cell component in breast
cancer tissues, their interaction with breast cancer cells has been less investigated …