Theory and simulation of multiphase coexistence in biomolecular mixtures

WM Jacobs - Journal of Chemical Theory and Computation, 2023 - ACS Publications
Biomolecular condensates constitute a newly recognized form of spatial organization in
living cells. Although many condensates are believed to form as a result of phase …

[HTML][HTML] Biomolecular condensates as drivers of membrane trafficking and remodelling

R Ravindran, SW Michnick - Current Opinion in Cell Biology, 2024 - Elsevier
Membrane remodelling is essential for the trafficking of macromolecules throughout the cell,
a process that regulates various aspects of cellular health and pathology. Recent studies …

Sequence-specific interactions determine viscoelasticity and ageing dynamics of protein condensates

I Alshareedah, WM Borcherds, SR Cohen, A Singh… - Nature Physics, 2024 - nature.com
Biomolecular condensates are viscoelastic materials. Here we investigate the determinants
of the sequence-encoded and age-dependent viscoelasticity of condensates formed by the …

Diffusiophoresis promotes phase separation and transport of biomolecular condensates

VS Doan, I Alshareedah, A Singh, PR Banerjee… - Nature …, 2024 - nature.com
The internal microenvironment of a living cell is heterogeneous and comprises a multitude of
organelles with distinct biochemistry. Amongst them are biomolecular condensates, which …

Molecular determinants of condensate composition

AS Holehouse, S Alberti - Molecular cell, 2025 - cell.com
Cells use membraneless compartments to organize their interiors, and recent research has
begun to uncover the molecular principles underlying their assembly. Here, we explore how …

Theory of the center-of-mass diffusion and viscosity of microstructured and variable sequence copolymer liquids

G Shi, KS Schweizer - Soft matter, 2023 - pubs.rsc.org
Biomolecular condensates formed through the phase separation of proteins and nucleic
acids are widely observed, offering a fundamental means of organizing intracellular …

Atomistic insights into the reentrant phase-transitions in polyuracil and polylysine mixtures

V Ramachandran, DA Potoyan - The Journal of Chemical Physics, 2024 - pubs.aip.org
The phase separation of protein and RNA mixtures underpins the assembly and regulation
of numerous membraneless organelles in cells. The ubiquity of protein–RNA condensates in …

Macromolecular crowding effects on protein dynamics

N Das, T Khan, B Halder, S Ghosh, P Sen - International Journal of …, 2024 - Elsevier
Macromolecular crowding experiments bridge the gap between in-vivo and in-vitro studies
by mimicking some of the cellular complexities like high viscosity and limited space, while …

Single fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates

T Wu, MR King, Y Qiu, M Farag, RV Pappu, MD Lew - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Biomolecular condensates are viscoelastic materials. Simulations predict that fluid-like
condensations are defined by spatially inhomogeneous organization of the underlying …

Polyelectrolyte–Carbon Dot Complex Coacervation

PK Pandey, A Sathyavageeswaran… - ACS Macro …, 2025 - ACS Publications
This Letter presents complex coacervation between the biopolymer diethylaminoethyl
dextran hydrochloride (DEAE-Dex) and carbon dots. The formation of these coacervates …