Oxazolidinone is a five-member heterocyclic ring with several biological applications in
medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most …

Abstract Uridine diphosphate-3-O-(hydroxymyristoyl)-N-acetylglucosamine deacetylase
(LpxC) is a metalloenzyme with zinc ions as cofactors and is a key enzyme in the essential …

The use of an acetylene (ethynyl) group in medicinal chemistry coincides with the launch of
the Journal of Medicinal Chemistry in 1959. Since then, the acetylene group has been …

Protoporphyrinogen oxidase (PPO, EC 1.3. 3.4) is a promising target for herbicide discovery.
Search for new compounds with novel chemotypes is a key objective for agrochemists …

UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) is a promising
drug target in Gram-negative bacteria. Previously, we described a correlation between the …

N, N′-Bis (pyridin-2-ylmethyl) oxalamide (BPMO) was found to be an apposite promoter for
the Cu-catalyzed N-arylation of oxazolidinones and primary and secondary amides with …

Fluoroquinolones are broad-spectrum antibiotics that target gyrase and topoisomerase IV,
involved in DNA compaction and segregation. We synthesized 28 novel norfloxacin …

UDP-3-O-((R)-3-hydroxymyristoyl)-N-glucosamine deacetylase (LpxC) is as an attractive
target for the discovery and development of novel antibacterial drugs to address the critical …

The involvement of 1, 3-dipolar cycloaddition (1, 3-DP), double bond migration, metathesis,
and nitrile oxide (including in situ-generated nitrile oxide) as dipoles, together with the C= C …

The lipopolysaccharide biosynthesis pathway is considered an attractive drug target against
the rising threat of multi-drug-resistant Gram-negative bacteria. Here, we report two novel …