While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

Nuclear export of mRNAs is a crucial step in the regulation of gene expression, linking
transcription in the nucleus to translation in the cytoplasm. Although important components …

Nuclear pore complexes are fundamental components of all eukaryotic cells that mediate
nucleocytoplasmic exchange. Determining their 110-megadalton structure imposes a …

A central question in biology is whether variability between genetically identical cells
exposed to the same culture conditions is largely stochastic or deterministic. Using image …

Selinexor is an oral inhibitor of the nuclear export protein exportin 1. Preclinical studies
demonstrated synergistic antimyeloma activity between selinexor and proteasome inhibitors …

Purpose Selinexor, a first-in-class, oral, selective exportin 1 (XPO1) inhibitor, induces
apoptosis in cancer cells through nuclear retention of tumor suppressor proteins and the …

2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Traditional anticancer chemotherapeutics targeting DNA replication and cell division have
severe side effects, but they have proved to be highly successful in treating some cancers …

Selinexor is a novel, first-in-class, selective inhibitor of nuclear export compound, which
blocks exportin 1 (XPO1) function, leads to nuclear accumulation of tumor suppressor …

Patients with relapsed or refractory (R/R) non-Hodgkin lymphoma (NHL) have a poor
prognosis and limited treatment options. We evaluated selinexor, an orally bioavailable, first …