Whole-brain annotation and multi-connectome cell typing of Drosophila

P Schlegel, Y Yin, AS Bates, S Dorkenwald, K Eichler… - Nature, 2024 - nature.com
The fruit fly Drosophila melanogaster has emerged as a key model organism in
neuroscience, in large part due to the concentration of collaboratively generated molecular …

Roadmap for focused ion beam technologies

K Höflich, G Hobler, FI Allen, T Wirtz, G Rius… - Applied Physics …, 2023 - pubs.aip.org
The focused ion beam (FIB) is a powerful tool for fabrication, modification, and
characterization of materials down to the nanoscale. Starting with the gallium FIB, which was …

Transforming descending input into behavior: The organization of premotor circuits in the Drosophila Male Adult Nerve Cord connectome

HSJ Cheong, K Eichler, T Stürner, SK Asinof… - bioRxiv, 2023 - biorxiv.org
In most animals, a relatively small number of descending neurons (DNs) connect higher
brain centers in the animal's head to circuits and motor neurons (MNs) in the nerve cord of …

Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster

N Eckstein, AS Bates, A Champion, M Du, Y Yin… - Cell, 2024 - cell.com
High-resolution electron microscopy of nervous systems has enabled the reconstruction of
synaptic connectomes. However, we do not know the synaptic sign for each connection (ie …

Dopamine-dependent plasticity is heterogeneously expressed by presynaptic calcium activity across individual boutons of the Drosophila mushroom body

AM Davidson, S Kaushik, T Hige - eneuro, 2023 - eneuro.org
The Drosophila mushroom body (MB) is an important model system for studying the synaptic
mechanisms of associative learning. In this system, coincidence of odor-evoked calcium …

What do the mushroom bodies do for the insect brain? Twenty-five years of progress

A Fiala, KR Kaun - Learning & Memory, 2024 - learnmem.cshlp.org
In 1998, a special edition of Learning & Memory was published with a discrete focus of
synthesizing the state of the field to provide an overview of the function of the insect …

Exploring the Asymmetric Body's Influence on Interval Timing Behaviors of Drosophila melanogaster

T Zhang, X Zhang, D Sun, WJ Kim - Behavior Genetics, 2024 - Springer
The roles of brain asymmetry in Drosophila are diverse, encompassing the regulation of
behavior, the creation of memory, neurodevelopment, and evolution. A comprehensive …

Multiple isoforms of the Activin-like receptor baboon differentially regulate proliferation and conversion behaviors of neuroblasts and neuroepithelial cells in the …

GG Lee, AJ Peterson, MJ Kim, MB O'Connor, JH Park - PloS one, 2024 - journals.plos.org
In Drosophila coordinated proliferation of two neural stem cells, neuroblasts (NB) and
neuroepithelial (NE) cells, is pivotal for proper larval brain growth that ultimately determines …

Brain size scaling through development in the whitelined sphinx moth (Hyles lineata) shows mass and cell number comparable to flies, bees, and wasps

IC Aksamit, F Dorigão-Guimarães… - Arthropod Structure & …, 2024 - Elsevier
Factors regulating larval growth and determinants of adult body size are described for
several holometabolous insects, but less is known about brain size scaling through …

A neuronal substrate for translating nutrient state and resource density estimations into foraging decisions

D Goldschmidt, I Tastekin, D Münch, JY Park… - BioRxiv, 2023 - biorxiv.org
Foraging animals must balance the costs of exploring their surroundings with the potential
benefits of finding nutritional resources. Each time an animal encounters a food source it …