E Chung, FA Yafi - Expert opinion on pharmacotherapy, 2022 - Taylor & Francis
Introduction Current clinical guidelines on Peyronie's disease (PD) advocate non-surgical treatment options as the first-line therapy despite inconsistent clinical outcomes when …
The tunica albuginea (TA) of the penis is an elastic layer that serves a structural role in penile erection. Disorders affecting the TA cause pain, deformity, and erectile dysfunction …
C Natale, DM McLellan, A Yousif… - Sexual Medicine …, 2021 - academic.oup.com
ABSTRACT Introduction Collagenase Clostridium histolyticum (CCH) is an injectable agent used to treat Peyronie's disease (PD) by enzymatically degrading the interstitial collagen in …
MK Li, JT Sigalos, DA Yoffe, N Modiri… - The Journal of …, 2023 - academic.oup.com
Background In the original clinical trials evaluating intralesional collagenase Clostridium histolyticum for Peyronie disease (PD), treatment protocols were limited to 8 injections. Aim …
EJ Choi, P Xu, FM El-Khatib, FA Yafi - Sexual Medicine Reviews, 2021 - academic.oup.com
Introduction Peyronie's disease (PD) is an inflammatory disorder of the tunica albuginea causing fibrotic changes including abnormal penile curvature, pain, and erectile dysfunction …
MYY Hu, JT Sigalos, DT Walker, MK Li… - Translational …, 2022 - ncbi.nlm.nih.gov
Background Peyronie's disease (PD) can be subdivided into acute and chronic phases. Intralesional collagenase Clostridium histolyticum has been shown to improve curvature in …
TP Furtado, V Osadchiy, JJ Andino… - Sexual Medicine …, 2024 - academic.oup.com
Abstract Introduction Collagenase Clostridium histolyticum (CCH) remains the only Food and Drug Administration–approved medical treatment for Peyronie's disease (PD). The …
JT Sigalos, MK Li, DA Yoffe, N Modiri… - The Journal of …, 2022 - auajournals.org
Purpose: The safety label for collagenase Clostridium histolyticum was updated to include postinjection acute lower back pain as an adverse event observed with intralesional therapy …
MJ Ziegelmann - The Journal of Sexual Medicine, 2023 - academic.oup.com
Peyronie's disease (PD) deformity comes in various shapes and sizes: curvature, shortening, and what is referred to as “volume loss deformity”(VLD). 1 VLD are focal or more …