Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

▪ Abstract Dendritic morphology has a profound impact on neuronal information processing.
The overall extent and orientation of dendrites determines the kinds of input a neuron …

The molecular mechanisms that determine the size and complexity of the neuronal dendritic
tree are unclear. Here, we show that the phosphoinositide-3′ kinase (PI3K)–Akt …

Abstract Docosahexanoic acid (22: 6n‐3; DHA) deficiency during development is associated
with impairment in learning and memory, suggesting an important role of DHA in neuronal …

The 26S proteasome is the chief site of regulatory protein turnover in eukaryotic cells. It
comprises one 20S catalytic complex (composed of four stacked rings of seven members) …

The insulinotropic hormone glucagon-like peptide-1 (7-36)-amide (GLP-1) has potent effects
on glucose-dependent insulin secretion, insulin gene expression, and pancreatic islet cell …

Insulin and its receptor are broadly expressed throughout the brain and have been
postulated to play a crucial role in synaptic plasticity. Although structural remodeling of …

Tumor necrosis factor (TNF)-α has been reported to modulate brain injury, but remarkably,
little is known about its effects on neurogenesis. We report that TNF-α strongly influences …

Motoneurons require neurotrophic factors for their survival and axonal projection during
development, as well as nerve regeneration. By using the axotomy-induced neuronal death …

Recent experiments in various cell types such as mammalian neutrophils and Dictyostelium
discoideum amoebae point to a key role for the lipid product of PI 3‐kinase, PIP3, in …