The Yin and Yang of ACE/ACE2 pathways: the rationale for the use of renin-angiotensin system inhibitors in COVID-19 patients

L Zamai - Cells, 2020 - mdpi.com
The article describes the rationale for inhibition of the renin-angiotensin system (RAS)
pathways as specific targets in patients infected by SARS-CoV-2 in order to prevent positive …

Renin–angiotensin system blockers, risk of SARS-CoV-2 infection and outcomes from CoViD-19: systematic review and meta-analysis

MMY Lee, KF Docherty, N Sattar… - European Heart …, 2022 - academic.oup.com
Aims This meta-analysis provides summary odds ratio (OR) estimates for associations
between treatment with (vs. without) renin–angiotensin system blockers and risk of severe …

Neprilysin is a mediator of alternative renin-angiotensin-system activation in the murine and human kidney

O Domenig, A Manzel, N Grobe, E Königshausen… - Scientific reports, 2016 - nature.com
Cardiovascular and renal pathologies are frequently associated with an activated renin-
angiotensin-system (RAS) and increased levels of its main effector and vasoconstrictor …

Which ones, when and why should renin-angiotensin system inhibitors work against COVID-19?

M Montanari, B Canonico, E Nordi, D Vandini… - Advances in Biological …, 2021 - Elsevier
The article describes the possible pathophysiological origin of COVID-19 and the crucial
role of renin-angiotensin system (RAS), providing several “converging” evidence in support …

Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease

B Trojanowicz, C Ulrich, F Kohler… - Nephrology Dialysis …, 2017 - academic.oup.com
Background: Increased levels of monocytic angiotensin-converting enzyme (ACE) found in
haemodialysis (HD) patients may directly participate in the pathogenesis of atherosclerosis …

Plasma and tissue angiotensin‐converting enzyme 2 activity and plasma equilibrium concentrations of angiotensin peptides in dogs with heart disease

É Larouche‐Lebel, KA Loughran… - Journal of veterinary …, 2019 - Wiley Online Library
Background Angiotensin‐converting enzyme 2 (ACE2) is a homologue of angiotensin‐
converting enzyme (ACE) and produces angiotensin peptides (APs), such as angiotensin 1 …

Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension

MM Rinschen, O Palygin, A El-Meanawy… - Nature …, 2022 - nature.com
Hypertension and kidney disease have been repeatedly associated with genomic variants
and alterations of lysine metabolism. Here, we combined stable isotope labeling with …

Effects of ramipril on the aldosterone/renin ratio and the aldosterone/angiotensin II ratio in patients with primary aldosteronism

Z Guo, M Poglitsch, D Cowley, O Domenig… - …, 2020 - Am Heart Assoc
The aldosterone/renin ratio (ARR) is currently considered the most reliable approach for
case detection of primary aldosteronism (PA). ACE (Angiotensin-converting enzyme) …

Use of renin-angiotensin system inhibitors is associated with reduction of fracture risk in hemodialysis patients

S Yamamoto, R Kido, Y Onishi, S Fukuma, T Akizawa… - PloS one, 2015 - journals.plos.org
Background Patients with chronic kidney disease, especially those undergoing dialysis
treatment and having secondary hyperparathyroidism, have a high risk of bone fracture. The …

Critical role of neprilysin in kidney angiotensin metabolism

CC Kaltenecker, O Domenig, C Kopecky… - Circulation …, 2020 - Am Heart Assoc
Rationale: Kidney homeostasis is critically determined by the coordinated activity of the
renin-angiotensin system (RAS), including the balanced synthesis of its main effector …