Provide herein are compounds and pharmaceutical composi tions suitable as modulators of
hemoglobin, methods and intermediates for their preparation, and methods for their use in …

3.236, 893 A 2/1966 Blout et al. 4,062,858 A 12/1977 Hoehn et al. 44 10.537 A 1 ()/1983
Kneen 4,478,834 A 1 ()/1984 Shroff et al. 4,535, 183 A 8/1985 Kneen 5,185.251 A 2/1993 …

(51) Int. CI. CO7D 498/08(2006. 01) C07D 491/107(2006. 01) C07D 403/04(2006. 01)
CO7D 401/04(2006. 01) CO7D 213/74(2006. 01)(52) US CI. CPC......... C07D 498/08 (2013 …

Provide herein are compounds and pharmaceutical compositions suitable as modulators of
hemoglobin, methods and intermediates for their preparation, and methods for their use in …

OTHER PUBLICATIONS US Appl. No. 14/216, 346, filed Mar. 17, 2014, Li et al. US Appl. No.
14/662, 145, filed Mar. 18, 2015, Metcalf. US Appl. No. 14/791, 017, filed Jul. 2, 2015, Qing …

Provide herein are compounds and pharmaceutical compo sitions Suitable as modulators of
hemoglobin, methods and intermediates for their preparation, and methods for their use in …

(63) Related US Application Data Continuation of application No. 14/836, 869, filed on Aug.
26, 2015, now Pat. No. 9, 776, 960, which is a continuation of application No. 14/599, 341 …

Provide herein are compounds and pharmaceutical compo sitions Suitable as modulators of
hemoglobin, methods and intermediates for their preparation, and methods for their use in …

Provided herein are high strength/high drug load tablets comprising 2-hydroxy-6-((2-(1-
isopropyl-1H-pyrazol-5-yl) pyridin-3-yl) methoxy) benzaldehyde (“Compound 1”), dispersible …

Provide herein are compounds and pharmaceutical compo sitions suitable as modulators of
hemoglobin, methods and intermediates for their preparation, and methods for their use in …