Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions

SK Sanganalmath, R Bolli - Circulation research, 2013 - Am Heart Assoc
Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …

Strategies for the chemical and biological functionalization of scaffolds for cardiac tissue engineering: a review

M Tallawi, E Rosellini, N Barbani… - Journal of the …, 2015 - royalsocietypublishing.org
The development of biomaterials for cardiac tissue engineering (CTE) is challenging,
primarily owing to the requirement of achieving a surface with favourable characteristics that …

Aged‐senescent cells contribute to impaired heart regeneration

FC Lewis‐McDougall, PJ Ruchaya… - Aging cell, 2019 - Wiley Online Library
Aging leads to increased cellular senescence and is associated with decreased potency of
tissue‐specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac …

Heart regeneration by endogenous stem cells and cardiomyocyte proliferation: controversy, fallacy, and progress

L He, NB Nguyen, R Ardehali, B Zhou - Circulation, 2020 - Am Heart Assoc
Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …

Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells

TS Li, K Cheng, K Malliaras, RR Smith, Y Zhang… - Journal of the American …, 2012 - jacc.org
Objectives: The goal of this study was to conduct a direct head-to-head comparison of
different stem cell types in vitro for various assays of potency and in vivo for functional …

Wharton's jelly-derived mesenchymal stem cells: phenotypic characterization and optimizing their therapeutic potential for clinical applications

DW Kim, M Staples, K Shinozuka, P Pantcheva… - International journal of …, 2013 - mdpi.com
Wharton's jelly (WJ) is a gelatinous tissue within the umbilical cord that contains
myofibroblast-like stromal cells. A unique cell population of WJ that has been suggested as …

Cerium oxide nanoparticles protect cardiac progenitor cells from oxidative stress

F Pagliari, C Mandoli, G Forte, E Magnani, S Pagliari… - ACS …, 2012 - ACS Publications
Cardiac progenitor cells (CPCs) are a promising autologous source of cells for cardiac
regenerative medicine. However, CPC culture in vitro requires the presence of …

Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure

K Urbanek, D Torella, F Sheikh… - Proceedings of the …, 2005 - National Acad Sciences
In this study, we tested whether the human heart possesses a cardiac stem cell (CSC) pool
that promotes regeneration after infarction. For this purpose, CSC growth and senescence …

[HTML][HTML] Drug and cell delivery for cardiac regeneration

CL Hastings, ET Roche, E Ruiz-Hernandez… - Advanced drug delivery …, 2015 - Elsevier
The spectrum of ischaemic cardiomyopathy, encompassing acute myocardial infarction to
congestive heart failure is a significant clinical issue in the modern era. This group of …

Cardiac regenerative capacity and mechanisms

K Kikuchi, KD Poss - Annual review of cell and developmental …, 2012 - annualreviews.org
The heart holds the monumental yet monotonous task of maintaining circulation. Although
cardiac function is critical to other organs and to life itself, mammals are not equipped with …