Analysis and optimization of drug solubility to improve pharmacokinetics

RK Thapa, HG Choi, JO Kim, CS Yong - Journal of Pharmaceutical …, 2017 - Springer
Solubility measurement is one of the key elements that need to be considered in drug
discovery and development process. Hence, its appropriate analysis and optimization is …

Smart systems for determination of drug's solubility

V Jouyban-Gharamaleki, A Jouyban… - Drug development …, 2019 - Taylor & Francis
The solubility of drugs is a crucial physicochemical property in the drug discovery or
development process and for improving the bioavailability of drugs. There are various …

Comparative Drug Solubility Studies Using Shake-Flask Versus a Laser-Based Robotic Method

E Rahimpour, M Moradi, A Sheikhi-Sovari, H Rezaei… - AAPS …, 2023 - Springer
Drug solubility is of central importance to the pharmaceutical sciences, but reported values
often show discrepancies. Various factors have been discussed in the literature to account …

Solubility and thermodynamics of lamotrigine in carbitol + water mixtures from T = (293.2 to 313.2) K

M Barzegar-Jalali, E Rahimpour… - Chemical …, 2019 - Taylor & Francis
The solubility of lamotrigine (LTG) are measured in aqueous mixtures of carbitol at
temperatures ranging from 293.2 to 313.2 K. LTG solubility increases with increasing mass …

Solubilization of bosentan using ethanol as a pharmaceutical cosolvent

S Sajedi-Amin, M Barzegar-Jalali… - Journal of Molecular …, 2017 - Elsevier
Solubility of bosentan in ethanol+ water mixtures was experimentally determined at five
different temperatures (293.2–313.2 K) with respect to the composition of the solvent …

Solubility of acetaminophen in 1-propanol + water mixtures at T = 293.2–313.2 K

F Pourkarim, SN Mirheydari, F Martinez… - Physics and Chemistry …, 2020 - Taylor & Francis
The mole fraction solubilities of acetaminophen (ACP) were measured in the binary solvent
mixtures of {1-propanol+ water} at T= 293.2–313.2 K. The Jouyban–Acree, Jouyban–Acree …

Solubility determination of tris (hydroxymethyl) aminomethane in water+ methanol mixtures at various temperatures using a laser monitoring technique

V Jouyban-Gharamaleki… - Journal of Chemical & …, 2014 - ACS Publications
The solubility of tris (hydroxymethyl) aminomethane (TRIS) in various mass fractions of
water+ methanol solvent mixtures at (293.2, 298.2, 303.2, 308.2, and 313.2) K was …

Automated solubility and crystallization analysis of non-UV active compounds: integration of evaporative light scattering detection (ELSD) and robotic sampling

R Chung, JE Hein - Reaction Chemistry & Engineering, 2019 - pubs.rsc.org
This article describes the integration of evaporative light scattering detection (ELSD) with
automated robotic sampling to obtain reliable and data-rich solubility and crystallization …

A laser monitoring technique for solubility study of ketoconazole in propylene glycol and 2-propanol mixtures at various temperatures

V Jouyban-Gharamaleki, A Jouyban, F Martinez… - Journal of molecular …, 2020 - Elsevier
In the current study, ketoconazole solubility profile is determined in the mixtures of propylene
glycol and 2-propanol at temperature range of 293.2–313.2 K by employing a laser-based …

Solubilization of celecoxib, lamotrigine and phenytoin using ethanol and a nonionic surfactant

V Jouyban-Gharamaleki, J Soleymani… - Journal of molecular …, 2017 - Elsevier
Using micellar medium as a solubilization technique is an influential approach for
solubilization of drugs with high hydrophobicity. It may be combined with cosolvency to …