Despite decades of declining mortality rates, lung cancer remains the leading cause of
cancer death in the United States. This article examines lung cancer incidence, stage at …

The RANK–RANKL–OPG system is a complex signaling pathway that plays a critical role in
bone metabolism, mammary epithelial cell development, immune function, and cancer …

Estrogens have been implicated in the pathogenesis of various cancers, with increasing
concern regarding the overall rising incidence of disease and exposure to environmental …

SOD1 is known as the major cytoplasmic superoxide dismutase and an anticancer target.
However, the role of SOD1 in cancer is not fully understood. Herein we describe the …

Lung cancer represents the world's leading cause of cancer deaths. Sex differences in the
incidence and mortality rates for various types of lung cancers have been identified, but the …

Simple Summary In this review, we present current knowledge of sex hormones in the
process of development of malignant diseases. The impact of sex hormones on immune …

Currently, immunotherapy based on PD-1/PD-L1 pathway blockade has improved survival
of non-small cell lung cancer (NSCLC) patients. However, differential responses have been …

Background Sp1, an important transcription factor, is involved in the progression of various
cancers. Our previous studies have indicated that Sp1 levels are increased in the early …

Lung cancer incidence and mortality have significantly increased in women worldwide. Lung
adenocarcinoma is the most common form of lung cancer globally. This type of lung cancer …

A multitude of evidence has suggested the differential incidence, prevalence and severity of
asthma between males and females. A compilation of recent literature recognized sex …