Satellite DNA consists of abundant tandem repeats that play important roles in cellular
processes, including chromosome segregation, genome organization and chromosome end …

DNA methylation is an important epigenetic mechanism that regulates gene expression. To
date, most DNA methylation studies have focussed on CpG islands in the gene promoter …

Histone lysine methylation has emerged as a critical player in the regulation of gene
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …

Inactivation of the RB protein is one of the most fundamental events in cancer. Coming to a
molecular understanding of its function in normal cells and how it impedes cancer …

The natural ends of linear chromosomes require unique genetic and structural adaptations
to facilitate the protection of genetic material. This is achieved by the sequestration of the …

Maintenance of genomic integrity is essential to ensure normal organismal development
and to prevent diseases such as cancer. Nuclear DNA is packaged into chromatin, and thus …

Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …

Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …

Telomere shortening occurs concomitant with organismal aging, and it is accelerated in the
context of human diseases associated with mutations in telomerase, such as some cases of …