Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

Although the basic aspects of protein synthesis are preserved in all kingdoms of life, there
are many important structural and functional differences between bacterial and the more …

Protein disorder plays a crucial role in signal transduction and is key for many cellular
processes including transcription, translation, and cell cycle. Within the intrinsically …

The long search for the environmental trigger of the endemic pemphigus foliaceus (EPF,
fogo selvagem) has not yet resulted in any tangible findings. Here, we searched for genetic …

Kaposi's sarcoma–associated herpesvirus (KSHV) is an oncogenic virus, the etiological
agent of Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). One of the key viral …

West Nile virus (WNV) is a (+) sense, single-stranded RNA virus in the Flavivirus genus.
WNV RNA possesses an m7GpppNm 5′ cap with 2′-O-methylation that mimics host …

Protein synthesis is a core biological process with stringent regulatory mechanisms at the
initiation phase in eukaryotic cells. Translation initiation is promoted through an interaction …

During protein synthesis, the genetic information is translated into a sequence of amino acid
building blocks that are sequentially attached to each other by a large ribonucleoprotein …

Recombinant proteins are typically produced using living cells. Alternatively, recombinant
proteins can be produced using cellular extracts in a “cell-free” protein expression system …

This is a manuscript-based thesis containing two peer review-published research articles
presented in Chapter 2 and Chapter 3, for which I am the co-first author or first author …