Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …

More than one million patients will manifest colorectal cancer (CRC) this year of which,
conservatively, approximately 3%(∼ 30,700 cases) will have Lynch syndrome (LS), the most …

Purpose Identifying individuals with Lynch syndrome (LS) is highly beneficial. However, it is
unclear whether microsatellite instability (MSI) or immunohistochemistry (IHC) should be …

The current understanding of familial colorectal cancer was limited to descriptions of affected
pedigrees until the early 1990s. A series of landscape‐altering discoveries revealed that …

High-penetrance mutations in several genes have been identified that contribute to
hereditary colorectal cancer. The role of these mutations in cancer pathogenesis is well …

The past two decades have brought many important advances in our understanding of the
hereditary susceptibility to cancer. Approximately 5–10% of all cancers are inherited, the …

Hereditary ovarian cancer accounts for at least 5% of the estimated 22,000 new cases of this
disease during 2009. During this same time, over 15,000 will die from malignancy ascribed …

Hereditary forms of colorectal cancer, as is the case with virtually all forms of hereditary
cancer, show extensive phenotypic and genotypic heterogeneity, a phenomenon discussed …

Gastric cancer's (GC) incidence shows large geographic differences worldwide with the
lowest rates occurring in most Western industrialized countries including the United States …

Background&Aims: Germline mutations in the DNA mismatch repair (MMR) genes MSH2,
MSH6, or MLH1 predispose to colorectal cancer (CRC) with an autosomal dominant …