Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …

Recanalization therapy is increasingly used in the treatment of acute ischemic stroke.
However, in about one third of these patients, recanalization is followed by …

2622 Stroke September 2017 cerebral edema and symptomatic intracranial hemorrhage,
which defines a malignant profile. 27 Because such patients have lowest rates of favorable …

Nitric oxide (NO) is a key signalling molecule in the regulation of cerebral blood flow. This
review summarises current evidence regarding the role of NO in the regulation of cerebral …

Conventional angiographic evaluation has advantages, including its reliable demonstration
of occlusion versus subtotal occlusion, well standardized recanalization grading, and high …

Clinical outcomes of patients with acute ischemic stroke depend in part on the extent of their
collateral circulation. A good collateral circulation has also been associated with greater …

Transient or permanent interruption of cerebral blood flow by occlusion of a cerebral artery
gives rise to an ischaemic stroke leading to irreversible damage or dysfunction to the cells …

Brain ischemia and reperfusion (I/R) is one of the most severe clinical manifestations of
ischemic stroke, placing a significant burden on both individuals and society. The only FDA …

The functional neural circuits are partially repaired after an ischemic stroke in the central
nervous system (CNS). In the CNS, neurovascular units, including neurons, endothelial …

The brain's collateral circulation consists of arterial anastomotic channels capable of
providing nutrient perfusion to brain regions whose normal sources of flow have become …