Background Plant-based meat analogues (PBMA) are promising to address the issue of
imbalance between global meat supply and demand. PBMA can contribute to an …

The limitations associated with natural enzyme catalysis have triggered the rise of the field of
protein engineering. Traditional rational design was based on the analysis of protein …

The enzyme soybean lipoxygenase (SLO) provides a prototype for deep tunneling
mechanisms in hydrogen transfer catalysis. This work combines room temperature X-ray …

This Perspective presents a review of our work and that of others in the highly controversial
topic of the coupling of protein dynamics to reaction in enzymes. We have been involved in …

Experiments and biomolecular simulations are revealing new and unexpected details of
how enzymes are adapted to specific temperatures. These findings are elucidating enzyme …

With the growing acceptance of the contribution of protein conformational ensembles to
enzyme catalysis and regulation, research in the field of protein dynamics has shifted toward …

Many enzymes display non-Arrhenius behavior with curved Arrhenius plots in the absence
of denaturation. There has been significant debate about the origin of this behavior and …

Both classical and quantum electrodynamics predict the existence of dipole-dipole long-
range electrodynamic intermolecular forces; however, these have never been hitherto …

Hydrogen sulfide (H2S) and nitric oxide (NO) are two relevant signal molecules that can
affect protein function throughout post-translational modifications (PTMs) such as …

Lipoxygenases (LOXs) catalyze the (per) oxidation of fatty acids that serve as important
mediators for cell signaling and inflammation. These reactions are initiated by a CH …