Translational regulation by uORFs and start codon selection stringency
In addition to the main, protein-coding, open reading frame (mORF), many eukaryotic
mRNAs contain upstream ORFs (uORFs) initiated at AUG or near-cognate codons residing …
mRNAs contain upstream ORFs (uORFs) initiated at AUG or near-cognate codons residing …
Non-AUG translation: a new start for protein synthesis in eukaryotes
Although it was long thought that eukaryotic translation almost always initiates at an AUG
start codon, recent advancements in ribosome footprint mapping have revealed that non …
start codon, recent advancements in ribosome footprint mapping have revealed that non …
Codon usage influences the local rate of translation elongation to regulate co-translational protein folding
Codon usage bias is a universal feature of eukaryotic and prokaryotic genomes and has
been proposed to regulate translation efficiency, accuracy, and protein folding based on the …
been proposed to regulate translation efficiency, accuracy, and protein folding based on the …
Conserved upstream open reading frame nascent peptides that control translation
Cells utilize transcriptional and posttranscriptional mechanisms to alter gene expression in
response to environmental cues. Gene-specific controls, including changing the translation …
response to environmental cues. Gene-specific controls, including changing the translation …
Codon usage regulates protein structure and function by affecting translation elongation speed in Drosophila cells
Codon usage biases are found in all eukaryotic and prokaryotic genomes and have been
proposed to regulate different aspects of translation process. Codon optimality has been …
proposed to regulate different aspects of translation process. Codon optimality has been …
Regulation of TRI5 expression and deoxynivalenol biosynthesis by a long non-coding RNA in Fusarium graminearum
Deoxynivalenol (DON) is the most frequently detected mycotoxin in cereal grains and
processed food or feed. Two transcription factors, Tri6 and Tri10, are essential for DON …
processed food or feed. Two transcription factors, Tri6 and Tri10, are essential for DON …
Non-AUG start codons: expanding and regulating the small and alternative ORFeome
X Cao, SA Slavoff - Experimental cell research, 2020 - Elsevier
Recent ribosome profiling and proteomic studies have revealed the presence of thousands
of novel coding sequences, referred to as small open reading frames (sORFs), in prokaryotic …
of novel coding sequences, referred to as small open reading frames (sORFs), in prokaryotic …
eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons
Codon usage bias is a universal feature of eukaryotic and prokaryotic genomes and plays
an important role in regulating gene expression levels. A major role of codon usage is …
an important role in regulating gene expression levels. A major role of codon usage is …
Machine learning predicts translation initiation sites in neurologic diseases with nucleotide repeat expansions
A number of neurologic diseases associated with expanded nucleotide repeats, including
an inherited form of amyotrophic lateral sclerosis, have an unconventional form of translation …
an inherited form of amyotrophic lateral sclerosis, have an unconventional form of translation …
Conservation and variability of the AUG initiation codon context in eukaryotes
G Hernández, VG Osnaya, X Pérez-Martínez - Trends in biochemical …, 2019 - cell.com
Selection of the translation initiation site (TIS) is a crucial step during translation. In the
1980s Marylin Kozak performed key studies on vertebrate mRNAs to characterize the …
1980s Marylin Kozak performed key studies on vertebrate mRNAs to characterize the …