The mesoscopic modeling of burst suppression during anesthesia

DTJ Liley, M Walsh - Frontiers in computational neuroscience, 2013 - frontiersin.org
The burst-suppression pattern is well recognized as a distinct feature of the mammalian
electroencephalogram (EEG) waveform. Consisting of alternating periods of high amplitude …

Phase space approach for modeling of epileptic dynamics

Y Wang, M Goodfellow, PN Taylor, G Baier - Physical Review E—Statistical …, 2012 - APS
Epileptic electroencephalography recordings can be described in terms of four prototypic
wave forms: fast sinusoidal oscillations, large slow waves, fast spiking, and spike waves. On …

Transition dynamics and optogenetic controls of generalized periodic epileptiform discharges

Z Shen, H Zhang, Z Cao, L Yan, Y Zhao, L Du, Z Deng - Neural Networks, 2022 - Elsevier
This paper aims to analyze possible mechanisms underlying the generation of generalized
periodic epileptiform discharges (GPEDs), especially to design targeted optogenetic …

A biologically constrained, mathematical model of cortical wave propagation preceding seizure termination

LR González-Ramírez, OJ Ahmed… - PLoS computational …, 2015 - journals.plos.org
Epilepsy—the condition of recurrent, unprovoked seizures—manifests in brain voltage
activity with characteristic spatiotemporal patterns. These patterns include stereotyped semi …

Transition dynamics and optogenetic control of epileptiform activity in a modified mean filed model of human cortex

Z Shen, Z Deng, L Yan, Y Zhao, L Du… - … in Nonlinear Science and …, 2023 - Elsevier
Physiological experiments have shown that inhibitory interneurons can induce and maintain
epileptiform activities, and different interneuron subtypes may be responsible for different …

Comparisons of electroencephalographically derived measures of hypnosis and antinociception in response to standardized stimuli during target-controlled propofol …

M Shoushtarian, MM Sahinovic… - Anesthesia & …, 2016 - journals.lww.com
BACKGROUND: Current electroencephalogram (EEG)-derived measures provide
information on cortical activity and hypnosis but are less accurate regarding subcortical …

Emergence of spatially heterogeneous burst suppression in a neural field model of electrocortical activity

I Bojak, ZV Stoyanov, DTJ Liley - Frontiers in systems neuroscience, 2015 - frontiersin.org
Burst suppression in the electroencephalogram (EEG) is a well-described phenomenon that
occurs during deep anesthesia, as well as in a variety of congenital and acquired brain …

[HTML][HTML] Evidence that alpha blocking is due to increases in system-level oscillatory damping not neuronal population desynchronisation

DTJ Liley, SD Muthukumaraswamy - NeuroImage, 2020 - Elsevier
The attenuation of the alpha rhythm following eyes-opening (alpha blocking) is among the
most robust features of the human electroencephalogram with the prevailing view being that …

Mechanisms and optogenetic control of rhythm slowing associated with Alzheimer's disease: some views from dynamical modeling

Z Shen, H Zhang, L Du, Y Zhang, X Sun - Nonlinear Dynamics, 2024 - Springer
This paper aims to explain and expand the dynamic mechanisms underlying the interesting
but controversial experimental phenomena in the optogenetic regulation of Alzheimer's …

Co-operative populations of neurons: mean field models of mesoscopic brain activity

DTJ Liley, BL Foster, I Bojak - Computational Systems Neurobiology, 2012 - Springer
While the basic units of computation in the brain are the neuronal cells, their sheer number,
complexity of structural organisation and widespread connectivity make it difficult, if not …