Toward better drug discovery with knowledge graph

X Zeng, X Tu, Y Liu, X Fu, Y Su - Current opinion in structural biology, 2022 - Elsevier
Drug discovery is the process of new drug identification. This process is driven by the
increasing data from existing chemical libraries and data banks. The knowledge graph is …

Idiosyncratic adverse reactions to antiepileptic drugs

G Zaccara, D Franciotta, E Perucca - Epilepsia, 2007 - Wiley Online Library
Idiosyncratic drug reactions may be defined as adverse effects that cannot be explained by
the known mechanisms of action of the offending agent, do not occur at any dose in most …

Knowledge, attitude and experience of pharmacist in the UAE towards pharmacovigilance

YM AlWorafi, S Hasan, NM Hassan… - Research Journal of …, 2021 - indianjournals.com
Objectives: The objective of the current study was to investigate the pharmacist's knowledge,
attitude, practice and experience towards pharmacovigilance. Methods: A cross-sectional …

Anaphylaxis during anesthesia in France: an 8-year national survey

PM Mertes, F Alla, P Tréchot, Y Auroy, E Jougla… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: More attention should be paid to rare serious adverse events such as
anaphylaxis to increase the safety of anesthesia. OBJECTIVE: To report the results of an 8 …

Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs

M Liu, Y Wu, Y Chen, J Sun, Z Zhao… - Journal of the …, 2012 - academic.oup.com
Objective Adverse drug reaction (ADR) is one of the major causes of failure in drug
development. Severe ADRs that go undetected until the post-marketing phase of a drug …

Detecting and Classifying Drug Interaction using Data mining Techniques

BT Yaseen, S Kurnaz, SR Ahmed - … International Symposium on …, 2022 - ieeexplore.ieee.org
Thousands of licensed drugs are now available to patients. The Warnings and Precautions
section of a medication's label was created to identify and characterize severe or clinically …

BSACI guidelines for the management of drug allergy

R Mirakian, PW Ewan, SR Durham… - Clinical & …, 2009 - Wiley Online Library
These guidelines have been prepared by the Standards of Care Committee (SOCC) of the
British Society for Allergy and Clinical Immunology (BSACI) and are intended for allergists …

Epidemiology of drug exposure and adverse drug reactions in two Swiss departments of internal medicine

K Fattinger, M Roos, P Vergères… - British journal of …, 2000 - Wiley Online Library
Aims To explore drug exposure, frequency of adverse drug reactions (ADRs), types of ADRs,
predisposing risk factors and ADR‐related excess hospital stay in medical inpatients …

Drug allergy

R Warrington, F Silviu-Dan, T Wong - Allergy, Asthma & Clinical …, 2018 - Springer
Drug allergy encompasses a spectrum of immunologically-mediated hypersensitivity
reactions with varying mechanisms and clinical presentations. This type of adverse drug …

The Nrf2–Keap1 defence pathway: role in protection against drug-induced toxicity

IM Copple, CE Goldring, NR Kitteringham, BK Park - Toxicology, 2008 - Elsevier
The metabolic biotransformation of xenobiotics to chemically reactive metabolites can, in
some instances, underlie the pathogenesis of certain adverse drug reactions, due to the …