Mechanochemical Transformations of Pharmaceutical Cocrystals: Polymorphs and Coformer Exchange

K Trzeciak, MK Dudek… - Chemistry–A European …, 2024 - Wiley Online Library
Transformations of solid samples under solvent‐free or minimal solvent conditions set the
future trend and define a modern strategy for the production of new materials. Of the various …

Phase solubility investigation and theoretical calculations on drug-drug cocrystals of carbamazepine with Emodin, Paeonol

D Huang, HCS Chan, Y Wu, L Li, L Zhang, Y Lv… - Journal of Molecular …, 2021 - Elsevier
Abstract Carbamazepine (CBZ), a Biopharmaceutics Classification System (BCS) class II
drug, is widely-used as a first line antiepileptic drug. Numbers of cocrystals have reported to …

Stabilizing L-Menthol by Cocrystallization: Supramolecular Cavities Succeeded in Retaining the Volatile Flavor

L Liu, Z Zhang, Y Cheng, Y Jiang, L Lu… - Crystal Growth & …, 2022 - ACS Publications
L-menthol is one of the most important flavoring additives with abundant plant sources. The
distinctive odor, cooling characteristic, and diversified biological activities attribute to its …

Carbamazepine/tartaric acid cocrystalline forms: When stoichiometry and synthesis method matter

L Roca-Paixão, NT Correia, F Danede… - Crystal Growth & …, 2022 - ACS Publications
A deep investigation of the cocrystallization of carbamazepine form III (CBZ) with dl-tartaric
acid (dl-TA) and l-tartaric acid (l-TA) has been undertaken. Different methods of synthesis …

Uncovering Cocrystal Formation and Competition Mechanism of Polyhydroxy Natural Products: Cases of Quercetin, Hesperidin, Resveratrol, and Curcumin

D Li, W Chen, L Zhou, L Xu, F He, JYY Heng… - Crystal Growth & …, 2024 - ACS Publications
Understanding drug cocrystal formation and its competitive mechanism is important for
improving the physicochemical properties of drugs. In this article, the cocrystal formation of …

A New Look at the Mechanism of Cocrystal Formation and Coformers Exchange in Processes Forced by Mechanical and/or Thermal Stimuli – ex situ and in situ …

MK Dudek, K Trzeciak, L Tajber, J Zając… - … A European Journal, 2024 - Wiley Online Library
Three different devices: ball mill, hot stage melting, and magic angle spinning (MAS) NMR
rotor were used for the preparation of ethenzamide (ET) cocrystals with glutaric acid (GLU) …

Gas-Assisted Cocrystal Desublimation

S Sanvordenker, S Borsadia, S Morris… - Crystal Growth & …, 2022 - ACS Publications
We report a novel process in which pharmaceutical cocrystals are sublimed, transported by
a carrier gas, and directed at high velocity at a substrate, where nano-and microscopic …

Solid-State Competitive Destabilization of Caffeine Malonic Acid Cocrystal: Mechanistic and Kinetic Investigations

MB Alsirawan, X Lai, R Prohens… - Crystal Growth & …, 2020 - ACS Publications
The main objective of this research is to investigate both the mechanism and the kinetics of
solvent-free destabilization of the model caffeine/malonic acid cocrystal (CA/MO 2: 1) in the …

Preparation, characterization and computational study of mosapride solvates

B Zhang, D Yang, S Yang, N Gong, G Du… - Journal of Molecular …, 2022 - Elsevier
In this work, four mosapride solvates were prepared, including mosapride 1-propanol
hydrate, mosapride 2-propanol hydrate, mosapride 1-butanol hydrate and mosapride 2 …

Novel manufacturing strategies for poorly water-soluble drugs

RC Thakkar - 2022 - repositories.lib.utexas.edu
The presented research focuses on innovative additive manufacturing platforms and
pharmaceutical formulations to improve the efficacy of the delivered drug. Drug discovery is …