The three-dimensional structures of the inactive protein precursors (zymogens) of the serine,
cysteine, aspartic, and metalloprotease classes of proteolytic enzymes are known …

The biosynthesis of RNA directed by an RNA template is a reaction that is unique to RNA
viruses. Although studies of polio virus RNA synthesis have been conducted in a somewhat …

ABSTRACT The 3C protease (3Cpro) from foot-and-mouth disease virus (FMDV), the
causative agent of a widespread and economically devastating disease of domestic …

The poliovirus RNA-dependent RNA polymerase, 3Dpol, is known to share a region of
sequence homology with all RNA polymerases centered at the GDD amino acid motif. The …

The ability of highly purified preparations of poliovirus RNA-dependent RNA polymerase,
3Dpol, to unwind RNA duplex structures was examined during a chain elongation reaction …

The assembly process of poliovirus occurs via an ordered proteolytic processing of the
capsid precursor protein, P1, by the virus-encoded proteinase 3CD. To further delineate this …

Human rhinoviruses (HRV) represent the single most important causative agent of the
common cold. The HRV genome encodes an RNA-dependent RNA polymerase (RdRp) …

A cDNA clone encoding the RNA polymerase of poliovirus has been expressed in
Escherichia coli under the transcriptional control of a T7 bacteriophage promoter. The …

A terminal adenylyl transferase (TATase) activity has been identified in preparations of
purified poliovirus RNA-dependent RNA polymerase (3Dpol). Highly purified 3Dpol is …

Poliovirus RNA replication requires the activities of a viral RNA-dependent RNA
polymerase, 3D pol, in conjunction with several additional viral and likely cellular proteins …