Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

Kinetochores are large protein complexes built on centromeric chromatin that mediate
chromosome segregation. The inner kinetochore, or constitutive centromere-associated …

The kinetochore plays an essential role in facilitating chromosome segregation during cell
division. This massive protein complex assembles onto the centromere of chromosomes and …

Polo-like kinase 1 (PLK1) is a serine/threonine kinase required for mitosis and cytokinesis.
As cancer cells are often hypersensitive to partial PLK1 inactivation, chemical inhibitors of …

Abstract The 16-subunit Constitutive Centromere-associated Network (CCAN)-based inner
kinetochore is well-known for connecting centromeric chromatin to the spindle-binding outer …

Bub1 is required for the kinetochore/centromere localization of two essential mitotic kinases
Plk1 and Aurora B. Surprisingly, stable depletion of Bub1 by∼ 95% in human cells …

The assembly of a functional kinetochore on centromeric chromatin is necessary to connect
chromosomes to the mitotic spindle, ensuring accurate chromosome segregation. This …

During mitosis, chromosomes assemble kinetochores to dynamically couple with spindle
microtubules. 1, 2 Kinetochores also function as signaling hubs directing mitotic progression …

Benzimidazole 1 (BUB1) and budding uninhibited by benzimidazole 1-related 1 (BUBR1)
are multidomain paralogs with key roles in chromosome alignment during mitosis and the …

The accurate distribution of the replicated genome during cell division is essential for cell
survival and healthy organismal development. Errors in this process have catastrophic …