The immunopathophysiology of acute graft-versus-host-disease
JLM Ferrara, KR Cooke, L Pan, W Krenger - Stem cells, 1996 - academic.oup.com
The major complication after allogeneic bone marrow transplantation (BMT) is the
development of graft-versus-host-disease (GVHD). This disease is initiated during the …
development of graft-versus-host-disease (GVHD). This disease is initiated during the …
Pathogenesis of acute graft-versus-host disease: cytokines and cellular effectors
JLM Ferrara - Journal of hematotherapy & stem cell research, 2000 - liebertpub.com
The pathogenesis of acute graft versus host disease (GVHD) is multistep process. This
review considers acute GVHD in three sequential steps: conditioning regimen, donor T cell …
review considers acute GVHD in three sequential steps: conditioning regimen, donor T cell …
G-CSF as immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases
A Franzke, W Piao, J Lauber, P Gatzlaff, C Könecke… - Blood, 2003 - ashpublications.org
Results from experimental models, in vitro studies, and clinical data indicate that granulocyte
colony-stimulating factor (G-CSF) stimulation alters T-cell function and induces Th2 immune …
colony-stimulating factor (G-CSF) stimulation alters T-cell function and induces Th2 immune …
Pharmacologic doses of granulocyte colony-stimulating factor affect cytokine production by lymphocytes in vitro and in vivo
EM Sloand, S Kim, JP Maciejewski… - Blood, The Journal …, 2000 - ashpublications.org
Peripheral blood stem cell (PBSC) transplantation is successful in improving engraftment
without increasing acute graft-versus-host disease (GVHD), despite much larger numbers of …
without increasing acute graft-versus-host disease (GVHD), despite much larger numbers of …
The role of G-CSF in adaptive immunity
A Franzke - Cytokine & growth factor reviews, 2006 - Elsevier
Granulocyte colony-stimulating factor (G-CSF) is a pleiotropic cytokine playing a major role
as regulator of hematopoiesis and innate immune responses. There is growing evidence …
as regulator of hematopoiesis and innate immune responses. There is growing evidence …
Granulocyte colony-stimulating factor–mobilized allogeneic stem cell transplantation maintains graft-versus-leukemia effects through a perforin-dependent pathway …
L Pan, T Teshima, GR Hill, D Bungard… - Blood, The Journal …, 1999 - ashpublications.org
Minimization of graft-versus-host disease (GVHD) with preservation of the graft-versus-
leukemia (GVL) effect is a crucial step to improve the overall survival of allogeneic bone …
leukemia (GVL) effect is a crucial step to improve the overall survival of allogeneic bone …
G-CSF–induced suppressor IL-10+ neutrophils promote regulatory T cells that inhibit graft-versus-host disease in a long-lasting and specific way
SM Perobelli, ACT Mercadante, RG Galvani… - The Journal of …, 2016 - journals.aai.org
Acute graft-versus-host disease (aGVHD) is the main complication of allogeneic
hematopoietic stem cell transplantation, and many efforts have been made to overcome this …
hematopoietic stem cell transplantation, and many efforts have been made to overcome this …
G-CSF given after haematopoietic stem cell transplantation using HLA-identical sibling donors is associated to a higher incidence of acute GVHD II–IV
M Remberger, N Naseh, J Aschan, L Barkholt… - Bone marrow …, 2003 - nature.com
The effect of granulocyte colony-stimulating factor (G-CSF), given after transplantation, was
studied in 155 patients transplanted with haematopoietic stem cells (HSCT) from HLA …
studied in 155 patients transplanted with haematopoietic stem cells (HSCT) from HLA …
Granulocyte–colony‐stimulatory factor: a strong inhibitor of natural killer cell function
L Schlahsa, Y Jaimes, R Blasczyk, C Figueiredo - Transfusion, 2011 - Wiley Online Library
BACKGROUND: The human cytokine granulocyte–colony stimulatory factor (G‐CSF) has
found widespread application in the medical treatment of neutropenia and to mobilize …
found widespread application in the medical treatment of neutropenia and to mobilize …
Granulocyte colony-stimulating factor affects the distribution and clonality of TRGV and TRDV repertoire of T cells and graft-versus-host disease
L Xuan, X Wu, Y Zhang, Z Fan, Y Ling, F Huang… - Journal of Translational …, 2011 - Springer
Background The immune modulatory effect of granulocyte colony-stimulating factor (G-CSF)
on T cells resulted in an unexpected low incidence of graft-versus-host disease (GVHD) in …
on T cells resulted in an unexpected low incidence of graft-versus-host disease (GVHD) in …