Apoptosis plays important roles in many facets of normal physiology in animal species,
including programmed cell death associated with fetal development or metamorphosis …

Inflammasomes are protein complexes that promote the maturation and release of pro‐
inflammatory cytokines and danger signals as well as pyroptosis in response to infections …

Apoptosis-associated speck-like protein containing a caspase recruitment domain
(ASC)/target of methylation-induced silencing/PYCARD represents one of only two proteins …

The PYRIN domain is a conserved sequence motif identified in more than 20 human
proteins with putative functions in apoptotic and inflammatory signalling pathways. The three …

Apoptosis (programmed cell death) plays important roles in many facets of normal
mammalian physiology. Host-pathogen interactions have provided evolutionary pressure for …

The PYRIN domain (PYD) is a protein–protein interaction domain, which belongs to the
death domain fold (DDF) superfamily. It is best known for its signaling function in innate …

Pyrin domain (PYD)-containing proteins are key components of pathways that regulate
inflammation, apoptosis, and cytokine processing. Their importance is further evidenced by …

The Death Domain Fold superfamily of evolutionarily conserved protein-protein interaction
domains consists of 4 subfamilies: the death domain, the death effector domain, the caspase …

The PAAD/DAPIN/pyrin domain is the fourth member of the death domain superfamily, but
unlike other members of this family, it is involved not only in apoptosis but also in innate …

ASC2 structure has been well defined by 1141 NOE experimental restraints. The model
consists of five alpha helices. α-Helices are connected by short random structure loops. The …