Nanobodies: next generation of cancer diagnostics and therapeutics

EY Yang, K Shah - Frontiers in Oncology, 2020 - frontiersin.org
The development of targeted medicine has greatly expanded treatment options and spurred
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …

Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development

SK Samrat, AM Tharappel, Z Li, H Li - Virus research, 2020 - Elsevier
The recent outbreak of the betacoronavirus SARS-CoV-2 has become a significant concern
to public health care worldwide. As of August 19, 2020, more than 22,140,472 people are …

In Situ Self‐Assembly of Bispecific Peptide for Cancer Immunotherapy

MD Wang, GT Lv, HW An, NY Zhang… - Angewandte Chemie …, 2022 - Wiley Online Library
Precise and effective manipulation of protein functions still faces tremendous challenges.
Herein we report a programmable peptide molecule, consisted of targeting and self …

Breast cancer immunotherapy: Current and novel approaches

K Barzaman, S Moradi-Kalbolandi… - International …, 2021 - Elsevier
The crucial role of the immune system in the progression/regression of breast cancer (BC)
should always be taken into account. Various immunotherapy approaches have been …

Extending traditional antibody therapies: Novel discoveries in immunotherapy and clinical applications

C Shin, SS Kim, YH Jo - Molecular Therapy-Oncolytics, 2021 - cell.com
Immunotherapy has been well regarded as one of the safer and antigen-specific anti-cancer
treatments compared to first-generation chemotherapy. Since Coley's discovery, researchers …

Nanobodies in cell-mediated immunotherapy: On the road to fight cancer

A Maali, M Gholizadeh, S Feghhi-Najafabadi… - Frontiers in …, 2023 - frontiersin.org
The immune system is essential in recognizing and eliminating tumor cells. The unique
characteristics of the tumor microenvironment (TME), such as heterogeneity, reduced blood …

Nanobodies; new molecular instruments with special specifications for targeting, diagnosis and treatment of triple-negative breast cancer

H Bakherad, F Ghasemi, M Hosseindokht… - Cancer Cell …, 2022 - Springer
Breast cancer is the most common type of cancer in women and the second leading cause
of cancer death in female. Triple-negative breast cancer has a more aggressive proliferation …

A PD-L1xCD3 bispecific nanobody as a novel T-cell engager in treating PD-L1 overexpression melanoma

B Li, S Wang, B Shan, B Li, F Li - Molecular Immunology, 2023 - Elsevier
The development of Immune checkpoint blockade (ICB) therapy and BRAF-and MEK-
targeted therapies has reshaped the survival outcomes of the patients with advanced …

Angiogenic biomolecules specific nanobodies application in cancer imaging and therapy; review and updates

A Shoari, M Tahmasebi, F Khodabakhsh… - International …, 2022 - Elsevier
Solid cancers are affiliate on angiogenesis for preservation. The FDA-approved monoclonal
antibodies like Bevacizumab are currently being administered effectively as inhibitors of …

Spatial transcriptomic analysis of tumour with high and low CAIX expression in TNBC tissue samples using GeoMx™ RNA assay

SAK Shamis, F Savioli, A Ammar… - Histology and …, 2024 - eprints.gla.ac.uk
Purpose. Prognostic significance and gene signatures associated with carbonic anhydrase
IX (CAIX) was investigated in triple negative breast cancer (TNBC) patients. Methods …